DNA/Transcription Based Apoptosis Inducers

• Bleomycin Sulfate
  A complex natural product antibiotic, approximates metals and dioxygen to produce a species capable of oxidatively damaging DNA and RNA.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200134	9041-93-4	C55H84N17O21S3•H2SO4	10 mg/50 mg

• Busulfan
  Antineoplastic bifunctional, DNA alkylating agent that causes DNA damage by cross-linking DNA and proteins. Causes double-base lesions mainly at 5’-GA-3’ and, to a lesser extent, at 5’-GG-3’ sequences. Forms an intrastrand cross-link at the 5’-GA-3’ sequence, and to monoalkylation. Induces normal human fibroblast senescence selectively through Erk and p38 pathways.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204658	55-98-1	C6H14O6S2	10 g

• Caylin-1
  A nutlin-3 analog which contains chlorine substituents at the 3 and 4 positions on two of the phenyl rings rather than a single 4-chloro as seen in nutlin-3. At high concentrations, compound inhibits the growth of HCT-116 cells, making it less potent than nutlin-3 in the same assay. At concentrations at or below 1 µM, caylin-1 promotes the growth of HCT-116 cells approximately 20% compared to untreated cells.2

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223878	n.n.	C30H28Cl4N4O4	1 mg/5 mg

• Caylin-2
  A nutlin-3 analog in which trifluoromethyl groups have been substituted for chlorine on the 2 phenyl rings. At high concentrations, compound inhibits the growth of HCT-116 cells with an IC₅₀ of approximately 8 µM, making it less potent than nutlin-3. Compound promotes the growth of HCT-116 cells approximately 40% compared to untreated cells.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223879	n.n.	C32H30F6N4O4	1 mg/5 mg

• Cisplatin
  The progenitor of a class of platinum-based antineoplastic agents that are believed to form inter- and intra-strand DNA adducts culminating in apoptosis.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200896	15663-27-1	Cl2H6N2Pt	100 mg/500 mg

• Daunorubicin • HCl (Daunomycin • HCl)
  A DNA intercalating anthracylcine natural product. Reported to demonstrate anti-proliferative activity against certain leukemias.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200921	23541-50-6	C27H29NO10 ·HCl	10 mg/50 mg

• Doxorubicin • HCl (Adriamycin)
  A DNA intercalator and broad-spectrum antitumor agent. Shown to downregulate expression of the oncogenes c-Myc and c-Jun.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200923	25316-40-9	C27H29NO11 ·HCl	5 mg/25 mg

• Folic Acid
  Important cofactor in the transfer of one-carbon moieties and plays big role in formation of S-adenosyl methionine and in the synthesis and repair of DNA and RNA.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204758	59-30-3	C19H19N7O6	10 g

• Hexamethonium bromide hydrate
  A nicotinic acetyl choline receptor antagonist. Induces apoptosis and inhibits the stimulatory effect of nicotine on endothelial cell DNA synthesis and proliferation. Also effective in preventing organophosphate intoxication.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205712	55-97-0	C12H30Br2N2 ·xH2O	10 g/25 g