DNA Topoisomerase Inhibitors

• 2',3'-Dideoxyadenosine-5'-triphosphate Lithium Salt
  Shown to be an inhibitor of chain elongation usually catalyzed by DNA polymerase I

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-288569	93939-70-9	C10H15LiN5O11P3	1 mg/5 mg

• Amsacrine hydrochloride
  Inhibits DNA topoisomerase II.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-214540	54301-15-4	C21H19N3O3S ·HCl	10 mg

• β-Lapachone
  Beta-Lapachone, a novel topoisomerase I inhibitor, does not stabilize the cleavable complex indicating a novel mode of action, unlike camptothecin (sc-200871).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200875	4707-32-8	C15H14O3	5 mg/25 mg

• Camptothecin
  Reversibly inhibits nuclear topoisomerase I by binding to and stabilizing the topoisomerase-DNA covalent complex. Reported antileukemic, antitumor, antiprotozoal, antimalarial activity, as well as inhibition of HIV, and induction of apoptosis.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200871	7689-03-4	C20H16N2O4	50 mg/250 mg

• Clinafloxacin Hydrochloride
  Clinafloxacin hydrochloride is an antimicrobial fluoroquinolone which inhibits topoisomerase IV.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202998	105956-99-8	C17H17ClFN3O3 ·HCl	100 mg/250 mg

• Cytosine β-D-arabinofuranoside hydrochloride
  An anti-leukemic agent which binds to topoisomerase I resulting in DNA fragmentation and inhibition of replication. In addition this compound does not have any effects on RNA synthesis.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221454	69-74-9	C9H13N3O5 ·HCl	25 mg/500 mg

• Dexrazoxane
  A cardioprotective compound against anthracyclines. It inhibits topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a (+)enantiomer of razoxane.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-252669	24584-09-6	C11H16N4O4	5 mg

• Ellipticine
  A polyaromatic DNA intercalator. Forms cytotoxic DNA adducts suggested to interfere with DNA replication. Inhibits DNA topoisomerase II. Inhibits cytochrome p450 CYP1A1 activity. Blocks p53 protein phosphorylation.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200878	519-23-3	C17H14N2	10 mg/50 mg

• Epirubicin Hydrochloride
  Cell-permeable antitumor antibiotic. A stereoisomer of Doxorubicin that exhibits reduced cardiotoxicity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203041	56390-09-1	C27H29NO11 ·HCl	5 mg

• Kaempferol
  A naturally occurring flavonoid shown to act as a potent reversible inhibitor of fatty acid synthase. lnduces apoptosis in cancer cell lines and PC12 cell research reports Kaempferol to protect against oxidative stress-induced cytotoxicity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202679	520-18-3	C15H10O6	25 mg

• ICRF-193
  A bisdioxopiperazine that is a catalytic noncleavable complex-forming inhibitor of DNA topoisomerase II that induces erythroid differentiation and apoptosis.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200889	21416-68-2	C12H18N4O4	1 mg/5 mg

• Irinotecan hydrochloride trihydrate
  Camptothecin drug family member. Inhibitor of Topo I (DNA topoisomerase I).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202186	136572-09-3	C33H38N4O6•HCl•3H2O	5 mg/25 mg

• Merbarone
  A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) while not damaging DNA or stabilizing DNA-topo II cleavable complexes (IC₅₀ = 20 µM for purified mammalian topo II versus IC₅₀ ~ 200 µM for topo I). Induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204076	97534-21-9	C11H9N3O3S	25 mg

• Mitoxantrone Dihydrochloride
  Antiviral, antibacterial, antiprotozoal. Induces DNA damage by intercalating into DNA and inhibiting topoisomerase II.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203136	70476-82-3	C22H28N4O6 ·2HCl	10 mg/50 mg

• Novobiocin Sodium (U-6591)
  An inhibitor of DNA gyrase and DNA topoisomerase II.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-358734	1476-53-5	C31H35N2NaO11	1 g/5 g

• Pirarubicin
  An analogue of the anthracycline anti-neoplastic doxorubicin. Intercalates into DNA and interacts with topoisomerase II and supressing DNA replication.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205810	72496-41-4	C32H37NO12	5 mg/10 mg

• Podophyllotoxin
  Potent inhibitor of microtubule assembly. Antineoplastic glucoside and antitumor agent. Also, DNA topoisomerase II inhibitor.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204853	518-28-5	C22H22O8	100 mg

• Sobuzoxane
  An inhibitor of DNA topoisomerase II which induces apoptosis.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-215862	98631-95-9	C22H34N4O10	5 mg/25 mg

• Topotecan
  A topoisomerase I inhibitor, and semisynthetic derivative of Camptothecin, shown to stabilize topoisomerase I/DNA cleavable complexes.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-338718	123948-87-8	C23H23N3O5	100 mg

• Topotecan Hydrochloride
  A topoisomerase I inhibitor. A water-soluble semisynthetic derivative of Camptothecin. Stabilizes topoisomerase I/DNA cleavable complexes.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204919	119413-54-6	C23H23N3O5 ·HCl	1 mg/5 mg