Cyclooxygenase Inhibitors

3,3',5,5'-Tetramethylbenzidine dihydrochloride dihydrate
An aromatic amine that undergoes oxidation by the higher oxidation states of heme peroxidases. Useful as a chromophore substrate in ELISA assays.
Katalog # CAS Nummer Summenformel Menge
sc-205527 207738-08-7 C₁₆H₂₀N₂··2HCl··2H₂O 100 mg/1 g
4'-Hydroxy Diclofenac
A metabolite of Aceclofenac. Specific inhibitor of COX-2, blocks prostaglandin E2 synthesis.
Katalog # CAS Nummer Summenformel Menge
sc-202423 64118-84-9 C₁₄H₁₁Cl₂NO₃ 100 µg
6-Methoxy-2-Naphthylacetic acid
6-Methoxy-2-Naphthylacetic acid is a Nabumetone metabolite and nonselective, competitive inhibitor of cyclooxygenase (COX).
Katalog # CAS Nummer Summenformel Menge
sc-200602 23981-47-7 C₁₃H₁₂O₃ 10 mg/50 mg
Acetaminophen
COX inhibitor; may be selective for COX-3. Widely used analgesic and antipyretic agent.
Katalog # CAS Nummer Summenformel Menge
sc-203425 103-90-2 C₈H₉NO₂ 100 mg
APHS
A selective inhibitor of COX-2. Covalently modifies the enzyme through Ser-530 acetylation. Demonstrated to block HIV-1 replication.
Katalog # CAS Nummer Summenformel Menge
sc-200668 209125-28-0 C₁₅H₁₈O₂S 10 mg/50 mg
Aspirin
An anti-inflammatory compound that inhibits NF-K&beta and cylooxygenase. NF-Kβ is a transcription factor that plays an important role in the expression of cellular and viral genes, which regulate the inflammatory response and infection.
Katalog # CAS Nummer Summenformel Menge
sc-202471 50-78-2 C₉H₈O₄ 5 g
COX-1 Inhibitor II
A cell-permeable benzenesulfonalide compound that acts as a catalytic site-targeting COX-1 more selectively than COX-2.
Katalog # CAS Nummer Summenformel Menge
sc-202556 304913-22-2 C₁₃H₁₃ClN₂O₂S 25 mg
COX-2 Inhibitor I
A cell-permeable potent and selective inhibitor of COX-2 from human monocytes and in whole blood. Displays only very weak activity against COX-1 from human platelets and in whole blood.
Katalog # CAS Nummer Summenformel Menge
sc-221436 n.n. C₁₈H₁₆ClNO₄S 5 mg
COX-2 Inhibitor II
A cell-permeable isoxazolyl-benzenesulfonamide compound that acts as a potent and highly selective inhibitor of COX-2 both in vitro and in vivo. Has been used extensively in various animal models to study the role of COX-2 in wound healing process.
Katalog # CAS Nummer Summenformel Menge
sc-221437 181696-33-3 C₁₆H₁₂F₂N₂O₃S 5 mg
COX-2 Inhibitor V, FK3311
Cell-permeable and orally available sulfonanilide that acts as a COX-2-selective non-steroidal anti-inflammatory drug (NSAID).
Katalog # CAS Nummer Summenformel Menge
sc-202557 116686-15-8 C₁₅H₁₃F₂NO₄S 5 mg
Diclofenac Sodium
An active metabolite of Aceclofenac, inhibits COX-1 and COX-2. Suppresses synthesis of prostaglandin E2. Blocks the formation of amyloidogenic TTR deposits.
Katalog # CAS Nummer Summenformel Menge
sc-202136 15307-79-6 C₁₄H₁₀Cl₂NO₂•Na 5 g/25 g
DuP-697
An anti-inflammatory agent that is a selective inhibitor for Cox-2. Found to induce apoptosis and halt cell growth by caspase-8 activation.
Katalog # CAS Nummer Summenformel Menge
sc-200680 88149-94-4 C₁₇H₁₂BrFO₂S₂ 5 mg/25 mg
Etodolac
A COX-2 inhibitor with anti-inflammatory and analgesic activity. Shown to inhibit growth and PCNA expression and induce cell cycle arrest in human hepatocellular carcinoma cell lines, in addition to suppressing the occurrence of aberrant crypt foci and tumors in colitis-induced tumorigenesis in rats.
Katalog # CAS Nummer Summenformel Menge
sc-204747 41340-25-4 C₁₇H₂₁NO₃ 100 mg/250 mg
Flurbiprofen
Mixture of S(+) and R(-) enantiomers. Cell-permeable, NSAID agent that acts as a potent inhibitor of COX. The S(+) enantiomer is reported to be more potent as a COX-2 inhibitor than R(-).
Katalog # CAS Nummer Summenformel Menge
sc-202158 5104-49-4 C₁₅H₁₃FO₂ 100 mg/1 g
FR 122047 hydrochloride hydrate
The hydrochloride salt preparation of FR 122047 shown to be a potent and selective Cox-1 inhibitor. Also reported to be an anti-inflammatory agent.
Katalog # CAS Nummer Summenformel Menge
sc-203584 130717-51-0 n.n. 10 mg/50 mg
FR122047 (hydrate)
A selective inhibitor of COX-1.
Katalog # CAS Nummer Summenformel Menge
sc-221628 n.n. C₂₃H₂₈ClN₃O₄S 1 mg/5 mg
Ibuprofen
Selective COX inhibitor. Inhibits PGH synthase-1 and -2 with comparable potency. Clinically useful NSAID. Inhibits neutrophil-dependent edema response of rabbit skin to C5a/PGE23.
Katalog # CAS Nummer Summenformel Menge
sc-200534 15687-27-1 C₁₃H₁₈O₂ 1 g/5 g
Indomethacin
A specific inhibitor of Cox-1 and an activator of PPARγ. Also shown to stabilize cholesterol-dependent nanoclusters and enhance phase separation in biological membranes.
Katalog # CAS Nummer Summenformel Menge
sc-200503 53-86-1 C₁₉H₁₆ClNO₄ 1 g/5 g
Indomethacin heptyl ester
A highly selective Cox-2 inhibitor that prevents arachidonic acid metabolism into prostaglandins. Also been shown to reduce expression and activity of P-glycoprotien.
Katalog # CAS Nummer Summenformel Menge
sc-221758 n.n. C₂₆H₃₀ClNO₄ 1 mg/5 mg
Ketorolac (tromethamine salt)
A non-selective COX inhibitor where the IC₅₀ values for human recombinant COX-1 and -2 are 31.5 µM and 60.5 µM, respectively.1
Katalog # CAS Nummer Summenformel Menge
sc-205360 74103-07-4 C₁₅H₁₃NO₃ ·C₄H₁₁NO₃ 500 mg/1 g
Lumaricoxib
A COX-2 selective inhibitor NSAID member of the arylalkanoic acid family of NSAIDs by binding to a separate site than that of other COX-2 inhibitors. Withdrawn from market amidst concerns of causing liver failure.
Katalog # CAS Nummer Summenformel Menge
sc-205736 220991-20-8 C₁₅H₁₃ClFNO₂ 100 mg/250 mg
Meloxicam
Shown to inhibit Cox-2, prostanoid synthesis, and erythrocyte PGD activity and contain non-steroidal anti-inflammatory properties.
Katalog # CAS Nummer Summenformel Menge
sc-200626 71125-38-7 C₁₄H₁₃N₃O₄S₂ 20 mg/100 mg
Naproxen
A potent, non-steroidal, non-selective anti-inflammatory compound that acts as a cyclooxygenase inhibitor, and inhibits both Cox-1 and Cox-2.
Katalog # CAS Nummer Summenformel Menge
sc-200506 22204-53-1 C₁₄H₁₄O₃ 1 g/5 g
Niflumic acid
Selective inhibitor of cyclooxygenase 2 (COX-2). NSAID, a potent anion channel blocker.
Katalog # CAS Nummer Summenformel Menge
sc-204820 4394-00-7 C₁₃H₉F₃N₂O₂ 5 g
Nimesulide
An anti-inflammatory COX inhibitor, with selectivity for COX-2 over COX-1.
Katalog # CAS Nummer Summenformel Menge
sc-200623 51803-78-2 C₁₃H₁₂N₂O₅S 5 g
NO-Indomethacin
A hybrid molecule of indomethacin and a nitric oxide (NO) donor; enhances the cancer chemopreventative activity of indomethacin.
Katalog # CAS Nummer Summenformel Menge
sc-205414 301838-28-8 C₂₈H₃₀ClN₃O₉S 1 mg/5 mg
NS-398
A cyclooxygenase-2 inhibitor. Has been correlated with a decrease in COX-2-mediated neuronal damage initiated by injury and toxins. a
Katalog # CAS Nummer Summenformel Menge
sc-200604 123653-11-2 C₁₃H₁₈N₂O₅S 5 mg/25 mg
Piroxicam
An effective and potent inhibitor of prostaglandin synthesis and a cyclooxygenase inhibitor. Also a non-steroidal compound with anti-inflammatory properties.
Katalog # CAS Nummer Summenformel Menge
sc-200576 36322-90-4 C₁₅H₁₃N₃O₄S 1 g/5 g
PPA
The product of peroxidase-catalyzed reduction of PPHP. Can be used as a reference standard for HPLC analysis of peroxidase assays.
Katalog # CAS Nummer Summenformel Menge
sc-222185 13159-16-5 C₁₁H₁₄O 500 µg/1 mg
(R)-Flurbiprofen
Has been shown to suppress prostate tumor cells by inducing p75NTR protein expression; inhibits the enzyme γ-secretase.
Katalog # CAS Nummer Summenformel Menge
sc-205487 51543-40-9 C₁₅H₁₃FO₂ 10 mg/50 mg
(S)-(+)-Flurbiprofen
Inhibits COX-1 and COX-2 more potently than (R)-enantiomer.
Katalog # CAS Nummer Summenformel Menge
sc-205503 51543-39-6 C₁₅H₁₃FO₂ 10 mg/50 mg
(S)-Ibuprofen
The active enantiomer of ibuprofen; shown to inhibit PGH synthase-1 and PGH synthase-2 with comparable potency, ID₅₀=8.9-14 and 7.2-8.2 μM respectively.
Katalog # CAS Nummer Summenformel Menge
sc-200612 51146-56-6 C₁₃H₁₈O₂ 1 g
(S)-Ketoprofen
An active form of ketoprofen that has been found to contain antiplatelet effects via inhibition of thromboxane B₂ generation.
Katalog # CAS Nummer Summenformel Menge
sc-200624 22161-88-5 C₁₆H₁₄O₃ 1 g
SC 560
A selective Cox-1 inhibitor that results in inhibition of PGE₂ and thromboxane B₂. Also shown to result in cell cycle arrest and eventually cause cell apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-202805 188817-13-2 C₁₇H₁₂CIF₃N₂O 5 mg
SC 58125
A selective and irreversible Cox-2 inhibitor that also inhibits Cox-1 in a reversible manner. Found to suppress cell proliferation by causing a progression delay at the G₂/M transition in the cell cycle.
Katalog # CAS Nummer Summenformel Menge
sc-204267 162054-19-5 C₁₇H₁₂F₄N₂O₂S 10 mg/50 mg
SC-236
Katalog # CAS Nummer Summenformel Menge
sc-222298 170569-86-5 C₁₆H₁₁ClF₃N₃O₂S 5 mg/25 mg
Sulindac Sulfide
A non-steroidal anti-inflammatory compound showing selective inhibition for COX-1 over COX-2. Also shown to be an inhibitor of gamma secretase, and Ras activation of Raf-1.
Katalog # CAS Nummer Summenformel Menge
sc-200118 32004-67-4 C₂₀H₁₇FO₂S 5 mg/25 mg
Sulindac Sulfone
Shown to be a lipoxygenase and Cox-2 inhibitor and also a potent apoptosis inducer. In addition, it may reduce the levels of secreted β-catenin and cell-cell adhesion in malignant tissues.
Katalog # CAS Nummer Summenformel Menge
sc-200120 59864-04-9 C₂₀H₁₇FO₄S 5 mg/25 mg
Tenidap
An anti-inflammatory agent that reduces A 23187-stimulated Leukotriene B₄ (LTB₄) and prostaglandin E₂ (PGE₂) synthesis.
Katalog # CAS Nummer Summenformel Menge
sc-204334 120210-48-2 C₁₄H₉N₂O₃SCl 10 mg/50 mg
N,N,N',N'-tetramethyl-p-phenylenediamine dihydrochloride
Oxidizable compound that serves as a reducing co-substrate for heme peroxidases.
Katalog # CAS Nummer Summenformel Menge
sc-205528 637-01-4 C₁₀H₁₆N₂ ·2HCl 5 g/10 g
Tryptanthrin
Inhibits prostaglandin and leukotriene synthesis, COX-2 activity and iNOS expression. Inhibits IFN-γ and IL-2 expression after staphylococcal enterotoxin B (SEB) treatment of Peyer’s patch lymphocytes.
Katalog # CAS Nummer Summenformel Menge
sc-202844 13220-57-0 C₁₅H₈N₂O₂ 1 mg/5 mg
Valeryl salicylate
Found to be an inhibitor of prostaglandin endoperoxide H synthases-1 and -2. Also shown to be a potent Cox-1 inhibitor.
Katalog # CAS Nummer Summenformel Menge
sc-205985 64206-54-8 C₁₂H₁₄O₄ 100 mg
ZLJ-6
A dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LO).
Katalog # CAS Nummer Summenformel Menge
sc-224468 1051931-39-5 C₁₂H₁₃N₃O₃S•CH₃SO₃H 1 mg/5 mg