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Home » Chemikalien » Cyclin-dependent Kinase (CDK) Inhibitors
 

Cyclin-dependent Kinase (CDK) Inhibitors

  • 2-Bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
    Cell permeable, unsymmetrical compound that displays antiproliferative properties. Shows little activity towards CaMKII, PKA and GSK-3β. Strong, selective and ATP-competitive inhibitor of CDK4/cyclin D1, CDK2/cyclin E and CDK1/cyclin B.
    Katalog #CAS NummerSummenformelMenge
    sc-220705n.n.C20H10BrN3O21 mg
  • 2-Hydroxybohemine
    Katalog #CAS NummerSummenformelMenge
    sc-205921471270-60-7C18H24N6O21 mg
  • 3-ATA
    Specific CDK4 inhibitor (IC50=3.1µM) inducing growth inhibition of p16-altered tumors.
    Katalog #CAS NummerSummenformelMenge
    sc-20241412982-10-85C13H10N2S1 mg/5 mg
  • 5-Iodo-indirubin-3'-monoxime
    Katalog #CAS NummerSummenformelMenge
    sc-221030n.n.C16H10IN3O21 mg
  • 9-Cyanopaullone
    Highly potent inhibitor of CDK1/cyclin B (IC50=25nM). Inhibits also CDK5/p25 (IC550=44nM ) and GSK-3β (IC50=10nM).
    Katalog #CAS NummerSummenformelMenge
    sc-221164n.n.C17H11N3O1 mg
  • Aloisine A
    An inhibitor of cyclin-dependent kinases and an anti-proliferative agent found to competitively inhibit binding of ATP to catalytic subunit of the CDKs.
    Katalog #CAS NummerSummenformelMenge
    sc-202451496864-16-5C16H17N3O1 mg
  • Aloisine, RP106
    Cell-permeable pyrrolo-pyrazine compound that exerts anti-proliferative effects. A potent, selective, ATP-competitive inhibitor of CDK1/cyclin B, CDK5/p25, and GSK-3.
    Katalog #CAS NummerSummenformelMenge
    sc-202452496864-15-4C17H19N3O1 mg/5 mg
  • Alsterpaullone
    A potent ATP-competitive and cell cycle cyclin-dependent kinase inhibitor, reported to be the most active paullone. Paullones belong to a family of benzazepinones, and are described to highly inhibit neuronal CDK5/p25 and GSK-3β.
    Katalog #CAS NummerSummenformelMenge
    sc-202453237430-03-4C16H11N3O31 mg/5 mg
  • Alsterpaullone, 2-Cyanoethyl
    An alsterpaullone derivative that acts as a highly potent, ATP-competitive, selective inhibitor of Cdk1/cyclin B and GSK-3β.
    Katalog #CAS NummerSummenformelMenge
    sc-203815852529-97-0C19H14N4O31 mg
  • Aminopurvalanol A
    A cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties (GI50 ~ 1.8 µM in the NCI 60-cell panel in vitro activity screen; potently inhibits the growth of KM12 colon cancer cells with a GI50 of 30 nM). Acts as a reversible and ATP-competitive inhibitor of Cdks (IC50 = 33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35), and displays ~ 100-fold greater selectivity over a panel of kinases tested (IC50 ≥ 2.4 µM). Shown to induce cell differentiation by preferentially targeting the G2/M-phase and act intracellularly by inhibiting both Cdks and MAPKs.
    Katalog #CAS NummerSummenformelMenge
    sc-223775220792-57-4C19H26ClN7O1 mg/5 mg
  • Arcyriaflavin A
    Potent inhibitor of CDK4 / cyclin D1 (IC50 = 59nM). Inhibits human cytomegalovirus (HCMV) replication in cell culture (IC50 = 200nM).
    Katalog #CAS NummerSummenformelMenge
    sc-202470118458-54-1C20H11N3O21 mg/10 mg
  • Aurora Kinase/Cdk Inhibitor
    A cell-permeable triazolylsulfonamido compound that acts a reversible, ATP-competitive kinase inhibitor with selectivities towards Aurora kinases and Cdk's.
    Katalog #CAS NummerSummenformelMenge
    sc-203829443797-96-4C15H12F2N6O3S ·CH3CN5 mg
  • AZD 5438
    Katalog #CAS NummerSummenformelMenge
    sc-361115602306-29-6C18H21N5O2S10 mg/50 mg
  • Benfluorene
    This is a selective inhibitor of CDK1 (IC50=28.8µM) and has P-glycoprotein-modulating properties (inhibitory activity ratio 9.5 at 7µM). It weakly inhibits CDK5 (6% inhibition at 10µM) with no effect on CDK2 and CDK4 (IC50>100µM).
    Katalog #CAS NummerSummenformelMenge
    sc-221292n.n.C20H15NO41 mg/5 mg
  • BML-259
    Potent inhibitor of CDK5 (IC50 = 64nM) and CDK2 / cyclin E (IC50 = 98nM)
    Katalog #CAS NummerSummenformelMenge
    sc-202505267654-00-2C14H16N2OS5 mg
  • Bohemine
    Katalog #CAS NummerSummenformelMenge
    sc-202506189232-42-6C18H24N6O1 mg/5 mg
  • Butyrolactone I
    An exogenous inhibitor of cyclin-dependent kinases, specifically Cdk2 and Cdc2 kinase. Competitive with ATP binding at CDKs.
    Katalog #CAS NummerSummenformelMenge
    sc-20153387414-49-1C24H24O7200 µg/1 mg
  • Cdc2-Like Kinase Inhibitor, TG003
    A benzothiazole agent that acts as a specific and ATP-competitive inhibitor of Clk family members. Shown to modify the regulation of alternative splicing.
    Katalog #CAS NummerSummenformelMenge
    sc-202528300801-52-9C13H15NO2S5 mg
  • Cdc7/Cdk9 Inhibitor
    A cell-permeable pyrrolopyridinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of Cdc7 and Cdk9.
    Katalog #CAS NummerSummenformelMenge
    sc-311303n.n.C12H11N3O5 mg
  • Cdk/CKI Inhibitor, (R)-DRF053
    A cell-permeable ATP-binding pocket-targeting (R)-Roscovitine derivative that is more potent than Roscovitine in inhibiting CDK1/CDK5/CK1 activity while maintaining selectivity against GSK-3α/β.The CDK/CK1 dual-specificity nature of (R)-DRF053 most likely accounts for its superior activity to that of (R)-Roscovitine against β40 production from APP-expressing N2A cells.
    Katalog #CAS NummerSummenformelMenge
    sc-221408n.n.C23H27N7O ·H2O5 mg
  • Cdk/Crk Inhibitor
    A cell-permeable pyrazolo-pyrimidinone compound that acts as a potent, selective, and ATP-competitive inhibitor of Cdks.
    Katalog #CAS NummerSummenformelMenge
    sc-203872784211-09-2C23H22Cl2N4O31 mg
  • Cdk1 Inhibitor
    Indolylmethylene-2-indolinone derivative with potent anti-proliferative properties. Selective, ATP-competitive inhibitor of Cdk1/cyclin B. Inhibits Cdk5. Binds the ATP pocket on the Cdk1 active site.
    Katalog #CAS NummerSummenformelMenge
    sc-202529220749-41-7C17H11ClN2O5 mg
  • Cdk1/2 Inhibitor III
    Cell-permeable triazolo-diamine compound with anti-proliferative properties in various human cancer cells. Highly potent, ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A.
    Katalog #CAS NummerSummenformelMenge
    sc-202530443798-55-8C15H13F2N7O2S21 mg
  • Cdk1/5 Inhibitor
    A 3-amino substituted pyrazoloquinoxaline that is a selective inhibitor of Cdk1 and Cdk5. Also inhibits GSK-3β. Does not inhibit Cdc25 phosphatase activity.
    Katalog #CAS NummerSummenformelMenge
    sc-20209440254-90-8C9H7N55 mg
  • Cdk2 Inhibitor II
    A potent and selective inhibitor of Cdk2.
    Katalog #CAS NummerSummenformelMenge
    sc-221409n.n.C14H11BrN4O3S1 mg
  • Cdk2 Inhibitor IV, NU6140
    Highly cell-permeable purine compound that displays anticancer properties and acts as a selective and ATP-competitive inhibitor of Cdks.
    Katalog #CAS NummerSummenformelMenge
    sc-202531444723-13-1C23H30N6O25 mg
  • Cdk2/5 Inhibitor
    An aminopyrimidine derivative that acts as a selective and ATP-competitive inhibitor of Cdk2/cyclin E and Cdk5/p25. Binds to the ATP-binding pocket of Cdk2. Does not affect the activities of c-Met, IGF-1 receptor tyrosine kinase, cAMP-dependent kinase, and ERK2 at concentrations as high as 100 µM.
    Katalog #CAS NummerSummenformelMenge
    sc-221410n.n.C10H11N5O2S ·HCl5 mg
  • Cdk4 Inhibitor
    A cell-permeable, unsymmetrical indolocarbazole compound that displays antiproliferative properties. Acts as a potent, selective, and ATP-competitive inhibitor of Cdk4/D1.
    Katalog #CAS NummerSummenformelMenge
    sc-203873546102-60-7C20H10BrN3O21 mg
  • Cdk4 Inhibitor III
    Cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor.
    Katalog #CAS NummerSummenformelMenge
    sc-202988265312-55-8C15H12N2O2S5 mg
  • Cdk4/6 Inhibitor IV
    A cell-permeable triaminopyrimidine compound shown to act as a reversible and ATP-competitive inhibitor of Cdk4/6 with selectivity over Cdk5/p35, v-abl, c-met, IGF-1R and IR.
    Katalog #CAS NummerSummenformelMenge
    sc-203874359886-84-3C27H32N6O5 mg
  • Cdk9 Inhibitor II
    An ATP-competitive inhibitor of inhibitor of Cdk9 and moderate inhibitor of similar enzymes including Cdk2-cyclin E.
    Katalog #CAS NummerSummenformelMenge
    sc-203326140651-18-9C9H10N6O5 mg
  • CDKi hydrochloride
    A potent and selective ATP competitive inhibitor of cycB-CDK1, cycE-CDK2, and cycD1-CDK4. This compound demonstrates significant inhibitory activity against a variety of tumor types in vitro and in vivo.
    Katalog #CAS NummerSummenformelMenge
    sc-21467470035-83-5 (non-salt)C4H6N4O ·xHCl5 mg
  • CVT-313
    Katalog #CAS NummerSummenformelMenge
    sc-221445199986-75-9C20H28N6O31 mg/5 mg
  • Flavopiridol
    Potent inhibitor of cyclin-dependent kinases (CDKs). Induces apoptosis in certain tumor cells. Interacts with multidrug resistance protein 1 (MRP1).
    Katalog #CAS NummerSummenformelMenge
    sc-202157146426-40-6C21H20ClNO55 mg/25 mg
  • GW8510
    An inhibitor of cyclin kinase 2 (CDK2) which prevents and/or reduces the side effects of chemotherapy (alopecia, plantar-palmar syndrome and mucositis).
    Katalog #CAS NummerSummenformelMenge
    sc-215122222036-17-1C21H15N5O3S21 mg/5 mg
  • Hymenidin
    Antagonist of serotonergic receptors. Inhibitor of CDK5/p25 (IC50=4µM) and GSK-3β (IC50=12µM).
    Katalog #CAS NummerSummenformelMenge
    sc-202177107019-95-4C11H12BrN5O1 mg
  • Indirubin-3'-monoxime
    Potent inhibitor of GSK-3&beta. Also inhibits CDK1 (p34cdc2) and CDK5. Reversibly arrests asynchronous HBL-100 cells at G22. Induces apoptosis in the mammary carcinoma cell line MCF-7.
    Katalog #CAS NummerSummenformelMenge
    sc-202660160807-49-8C16H11N3O21 mg/5 mg
  • Indirubin-3'-monoxime-5-sulphonic Acid
    A potent inhibitor of Cdk1 and Cdk5 and glycogen synthase kinase-3β. The inhibition is competitive with respect to ATP.
    Katalog #CAS NummerSummenformelMenge
    sc-221753331467-05-1C16H11N3O5S1 mg
  • Indirubin-5-sulfonic acid sodium salt
    Cyclin-dependent kinases (CDKs) inhibitors, with selectivity for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, CDK5/p35 and GSK-3β.
    Katalog #CAS NummerSummenformelMenge
    sc-221755n.n.C16H9N2O5S ·Na1 mg/5 mg
  • Iso-olomoucine
    Olomoucine (sc-3509) is a potent and selective inhibitor of cdc2, cdk and other cyclin related kinases. Iso-olomoucine is a negative control compound for olomoucine.
    Katalog #CAS NummerSummenformelMenge
    sc-201528101622-50-8C15H18N6O5 mg/25 mg
  • Isogranulatimide
    Cell-permeable alkaloid containing indole/maleimide/imidazole skeleton that acts as a potent and ATP-competitive inhibitor of Chk1 and GSK-3β.
    Katalog #CAS NummerSummenformelMenge
    sc-202667244148-46-7C15H8N4O21 mg
  • Indirubin
    Indirubin, also known as isoindigotin, is an inhibitor of Cdc2 p34 and Cdk5 (cyclin-dependent kinases (CDKs) 1 and 5), and GSK-3å (glycogen synthase kinase-3 (GSK-3)).
    Katalog #CAS NummerSummenformelMenge
    sc-201531479-41-4C16H10N2O25 mg/25 mg
  • Kenpaullone
    A novel kinase inhibitor initially defined as CDK inhibitors (CDK5 IC50=0.85 µM, CDK1 IC50=0.4 µM). More recently kenpaullone has been found to be a useful GSK-3β inhibitor (IC50=23 nM).
    Katalog #CAS NummerSummenformelMenge
    sc-200643142273-20-9C16H11BrN2O1 mg/5 mg
  • N-6-(δ2-Isopentenyl)-adenine
    Weakly active olomoucine analog for structure-activity analyses in the olomoucine series. Regulator of plant growth.
    Katalog #CAS NummerSummenformelMenge
    sc-2796692365-40-4C10H13N51 g/5 g
  • NSC 625987
    Cyclin-dependent kinase (cdk) 4 inhibitor (IC50 = 0.2 μM at cdk4/cyclin D1). It displays > 500-fold selectivity over cdk2 (IC50 > 100 μM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).
    Katalog #CAS NummerSummenformelMenge
    sc-203653141992-47-4C15H13NO2S5 mg
  • NU2058
    A competitive inhibitor of CDK1/2 with respect to ATP. Also shown to affect p53-dependent transcription and halt cell growth at the G1 phase.
    Katalog #CAS NummerSummenformelMenge
    sc-202744161058-83-9C12H17N5O5 mg/25 mg
  • NU6027
    An selective inhibitor of cyclin-dependent kinase-2 (CDK2).
    Katalog #CAS NummerSummenformelMenge
    sc-215591220036-08-8C11H17N5O25 mg
  • NU6102
    This is 1,000-fold more potent inhibitor of CDK1/cyclin B (IC50=9.5nM) and CDK2/cyclin A3 (IC50=5.4nM) than NU2058. It is selective for CDK1 and CDK2 compared to CDK4/D1 (IC50=1.6µM), DYRK1A (IC50=0.9µM), PDK1 (IC50=0.8µM) and ROCKII (IC550=0.6µM).
    Katalog #CAS NummerSummenformelMenge
    sc-222082444722-95-6C18H22N6O3S1 mg/5 mg
  • Olomoucine II
    Selective inhibitor of CDK1/cyclin B. Potent cytotoxin in tumor cells.
    Katalog #CAS NummerSummenformelMenge
    sc-202750500735-47-7C19H26N6O21 mg/5 mg
  • Olomoucine, Dimethylamino-
    Negative control for olomoucine.
    Katalog #CAS NummerSummenformelMenge
    sc-222099n.n.C17H23N75 mg
  • N9-Isopropyl-olomoucine
    Inhibitor of CDK1/cyclin B (IC50=2µM) and CDK5/p35 (IC50=3µM).
    Katalog #CAS NummerSummenformelMenge
    sc-202264158982-15-1C17H22N6O1 mg/5 mg
  • Pfmrk Inhibitor, WR 216174
    Oxindole compound acting as an ATP-competitive and selective inhibitor of Pfmrk. Exhibits low activity against PfPK5 and human Cdk1/B.
    Katalog #CAS NummerSummenformelMenge
    sc-204183601487-96-1C16H9BrFNO25 mg
  • PNU 112455A hydrochloride
    Katalog #CAS NummerSummenformelMenge
    sc-222182n.n.C10H11N5O2S•HCl1 mg/5 mg
  • Purvalanol A
    Katalog #CAS NummerSummenformelMenge
    sc-224244212844-53-6C19H25ClN6O1 mg
  • Purvalanol B
    Katalog #CAS NummerSummenformelMenge
    sc-361300212844-54-7C20H25ClN6O310 mg/50 mg
  • (R)-DRF053 dihydrochloride
    A potent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively). Shown to be selective over GSK-3 α/β (IC50= 4.1 μM). Also shown to inhibit amyloid-β production in N2A-APP695 cells.
    Katalog #CAS NummerSummenformelMenge
    sc-2962481056016-06-8C23H27N7O•2HCl•xH2O10 mg/50 mg
  • RO-3306
    Shown to be an inhibitor of CDK1/cyclin B1 and CDK1/cyclin A. Reversibly arrests human cells at the G2/M border of the cell cycle. Allows for effective cell synchronisation in early mitosis.
    Katalog #CAS NummerSummenformelMenge
    sc-358700872573-93-8C18H13N3OS21 mg/5 mg
  • Roscovitine
    Inhibits CDK1, CDK2, CDK5, M-phase promoting factor kinsase activity, and effects calcium channel gating.
    Katalog #CAS NummerSummenformelMenge
    sc-24002186692-46-6C19H26N6O1 mg/5 mg
  • SU 9516
    This is a cell permeable, potent, selective and ATP-competitive inhibitor of CDK2/cyclin A (IC50=22nM), CDK1/cyclin B (IC50=40nM) and CDK4/cyclin D1 (IC50=200nM). It has no effect on the activity of PKC, p38, PDGFRβ and EGFR (IC50>10µM). Displays anti-proliferative and pro-apoptotic properties in tumor cells and inhibits proliferation of growth factor-stimulated colon carcinoma cells. It does this by binding to CDK2 and thus preventing the phosphorylation of pRb and its dissociation from E2F.
    Katalog #CAS NummerSummenformelMenge
    sc-222330377090-84-1C13H11N3O25 mg/25 mg
  • SU9516
    A selectively potent ATP-competitive inhibitor of CDKs; displays anti-proliferative and proapoptotic properties in tumor cells.
    Katalog #CAS NummerSummenformelMenge
    sc-204905666837-93-0C13H11N3O25 mg
  • WHI-P180, Hydrochloride
    A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC50 = 1 µM) by blocking the ATP site.
    Katalog #CAS NummerSummenformelMenge
    sc-204396211555-08-7C16H15N3O3500 µg/1 mg