Cyclic AMP and Cyclic GMP Analogs

• 8-Bromo-cAMP
  A cell-permeable cAMP analog which is more resistant to hydrolysis by cyclic nucleotide phosphodiesterases than cAMP. Activates cAMP-dependent protein kinase.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201564	76939-46-3	C10H10BrN5O6P.Na	10 mg/50 mg

• 8-Bromo-cGMP
  A cell-permeable cGMP analog with greater resistance to hydrolysis by phosphodiesterases than cGMP. It has been shown to preferentially activate cGMP-dependent protein kinase.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200316	51116-01-9	C10H10BrN5O7P ·Na	10 mg/50 mg

• 8-Bromoadenosine 3',5'-cyclic Monophosphothioate, Sp-Isomer sodium salt
  Metabolically resistant activator of PKA (cAMP agonist). No metabolic side effects as observed with dibutyryl-cAMP or 8-Br-cAMP. More lipophilic and membrane permeant than Sp-cAMPS.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202435	127634-20-2	C10H10BrN5O5PSNa	1 mg/5 mg

• 8-Bromoguanosine 3', 5' -cyclic monophosphoric acid
  This product is known to activate cGMP-dependent protein kinase. In human platelets, it has been shown to inhibit arachidonic acid release that is induced by thrombin. It has been reported to slow down or inhibit oscillations of intracellular calcium in response to acetylcholine in tracheal smooth muscle cells. It has been observed to mimic the effect of drugs that generate nitric oxide. It is membrane-permeable, and offers greater hydrolysis resistance by phosphodiesterases than cGMP.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-291685	31356-94-2	C10H11BrN5O7P	5 mg/10 mg

• 8-Chloroadenosine 3',5'-Cyclic Monophosphate sodium salt
  A site-selective cAMP analog that inhibits various cancer cell lines such as HT29 colorectal cells and ZR-75-1 breast carcinoma, which is due to selective modulation of protein kinase A isoenzymes.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202437	41941-56-4	C10H10ClN5O6P ·Na	1 mg/5 mg

• 8-CPT-cAMP
  An efficient activator of cyclic-GMP-dependent protein kinase (cGMP-PK) and cAMP-PK. Acts as a robust inhibitor of cyclic GMP-specific phosphodiesterase (PDE VA) (IC₅₀= 0.9 microM).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201569	93882-12-3	C16H14ClN5NaO6PS	20 mg/100 mg

• Adenosine 3′,5′-cyclic monophosphate sodium salt monohydrate
  The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-291840	37839-81-9	C10H11N5NaO6P ··· ·H2O	25 mg/100 mg

• Dibutyryl-cAMP
  An analog of cyclic AMP that stimulates cAMP-dependent protein kinase and the activity of the Na⁺,K⁺-pump.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201567	16980-89-5	C18H23N5O8P··Na	20 mg/100 mg

• Dibutyryl-cGMP
  A membrane permeable cGMP analog used in various experiments to model cGMP interactions and effects. Also shown to inhibit the contractile effect of cholecystokinin octapeptide.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200321	51116-00-8	C18H23NaN5O9P	10 mg/50 mg

• Guanosine-2'(3')-monophosphate disodium salt
  A mixture of the 2' and 3'-isomers of GMP.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-295031	6027-83-4	C10H12N5O8PNa2	1 g/5 g

• Rp-8-Br-cGMPS
  A cell permeable cGMP analog which blocks cGMP-dependent protein kinase. Shown to inhibit relaxation elicited by 8-BR-cGMP of rabbit aorta.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200323	150418-07-8	C10H10BrN5O6PS•Na	500 µg

• Sp-5,6-DCI-cBiMPS
  Sp-5,6-DCI-cBiMPS is a phosphodiesterase-sensitive cAMP analog and potent activator of cAMP-dependent protein kinase.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201566	120912-54-1	C12H10Cl2N2O5PSNa	1 mg

• Sp-8-Br-cGMPS
  Sp-8-Br-cGMPS is a cell-permeable, unspecific activator of cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG) 1α. It has been shown to be resistant to cyclic nucleotide phophodiesterases.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200324	153660-03-8	C10H10BrN5O6PS ·Na	500 µg

• Sp-cAMPS
  A stimulatory diastereoisomer of adenosine 3',5'-(cyclic)phosphorothioate and has been shown to contain axial exocyclic sulphur atom. Also noted to activate phosphotransferase and cAMP-dependent protein kinase.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201571	93602-66-5	C10H11N5O5PS··C6H16N	1 mg