| | Cholinergics
- 1-Acetyl-4-methylpiperazine hydrochloride
Acetylcholine analog that acts as a nAChR agonist. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203759 | 60787-05-5 | C7H14N2O.HCl | 10 mg/50 mg |
- 1-Benzyl-1-methyl-4-cyclopentylmethoxycarbonyl-piperidinium bromide
Strong inhibitor of the active transport of acetylcholine by synaptic vesicles.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-220461 | n.n. | C20H30BrNO2 | 5 mg |
- 4-Acetyl-1,1-dimethylpiperazinium iodide
Structural analog of acetylcholine that acts as a nicotinic agonist (Ki = 29.9 nM at α4β2). Upregulates the number of α4β2 binding sites in M10 cells in vitro by 440%.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203473 | 75667-84-4 | C8N17IN2O | 10 mg/50 mg |
- 4-DAMP
4-DAMP is a muscarinic receptor antagonist. Shown to be a useful ligand for labeling the M1 and M3 muscarinic receptor subtypes.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200167 | 1952-15-4 | C21H26INO2 | 50 mg |
- 5-IODO-A-85380 dihydrochloride hydrate
A highly potent and subtype-selective agonist for the α4β2 and α6β2 nicotinic acetylcholine receptors; activates α-CTx-MII-sensitive and -insensitive components of [3H]dopamine release.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203478 | 213764-92-2 | C9H11IN2O ·2HCl | 5 mg |
- 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative
Precursor to the highly potent and selective ligand for the α4β2 nicotinic receptor, 5-Iodo-A-85380. Suitable for radioiodination.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203479 | 213766-21-3 | C17H28N2O3Sn | 200 µg |
- 5-Methylfurmethide
Potent muscarinic agonist.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202891 | 1197-60-0 | C9H16INO | 10 mg/50 mg |
- 14-Acetylvirescenine from Delphinium sp.
Blocks the propagation of the action potential at the nicotinic cholinoreceptors of vegetative ganglia and neuro-muscular junctions. Has hypotensive and curare-like action.
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-297973 | 71609-79-5 | C25H39NO7 | 10 mg |
- A-85380 dihydrochloride
A potent and selective neuronal nicotinic acetylcholine receptor (nAChR) agonist.
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-300146 | n.n. | C9H14Cl2N2O | 5 mg |
- α-NETA
Potent, fluorescent inhibitor of choline acetyltransferase.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221190 | 31059-54-8 | C16H20INO | 5 mg/25 mg |
- AB-MECA
This is a high affinity A3 adenosine receptor agonist.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-239176 | 152918-26-8 | C18H21N7O4 | 1 mg |
- Acephate
Anticholinesterase insecticide that produces cholinotoxicity. Displays weak inhibition of rat acetylcholinesterase (AChE) but potently inhibits cockroach AChE| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203800 | 30560-19-1 | C4H10NO3PS | 50 mg |
- Acetyl-L-carnitine chloride
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-210747 | 5080-50-2 | C9H18NClO4 | 1 g |
- (±)-Acetylcarnitine chloride
A weak cholinergic agonist. Acylcarnitines are important intermediates in lipid metabolism.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203495 | 2504-11-2 | C9H18CINO4 | 100 mg |
- Acetylcholine chloride
A cholinergic neurotransmitter that can induce the opening of calcium channels, as well as act on nicotinic and muscarinic acetylcholine receptors.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202904 | 60-31-1 | C7H16ClNO2 | 5 g/25 g |
- Acetylcholine-d9 Chloride
Cholinergic.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-217569 | 344298-95-9 | C7H16ClNO2 | 5 mg |
- Acetylethylcholine mustard hydrochloride
An inhibitor of choline acetyl-transferase. A precursor for ethylcholine mustard aziridinium ion (AF-64A). An irreversible ligand for the high affinity choline transport system. And a specific presynaptic long action cholinotoxin.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-281685 | 103994-00-9 | C8H16CINO2•HCI | 5 mg/25 mg |
- Acetylthiocholine iodide
This compound is an acetylcholinesterase substrate and nicotinic acetylcholine receptor agonist.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-208323 | 1866-15-5 | C7H16INOS | 1 g/5 g |
- AF-DX 116
SelectiveM2 antagonist| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-223772 | 102394-31-0 | C24H31N5O2 | 10 mg |
- AF-DX 384
Potent M2/M4 selective antagonist (pKi values are 8.22, 8.00, 7.51, 7.18 and 6.27 at human M2, M4, M1, M3 and M5 receptors respectively).| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203498 | 118290-27-0 | C28H42N6O5S | 10 mg/50 mg |
- Ambenonium dichloride
A selective rapidly reversible noncovalent inhibitor of AChE. Demonstrates high affinity at AChE (IC50 = 0.698 nM) and lower affinity at BChE (IC50 = 8.20 μM).| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203507 | 52022-31-8 | C28H42Cl4N4O2•xH2O | 10 mg/50 mg |
- Aminobenztropine
Muscarinic ligand displaying high affinity. Useful in affinity purification of muscarinic cholinergic receptors.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-300194 | 88097-86-3 | C21H26N2O | 50 mg |
- (±)-Anatoxin A
A cyanotoxin agonist of nicotinic acetylcholine receptors. Produces neurotoxicity through overstimulation of cholinergic neurons.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200185 | 64285-06-9 | C10H15NO··C4H4O4 | 1 mg |
- AQ-RA 741
High affinity, selective muscarinic M2 receptor antagonist (pKi values are 8.3, 7.7 and 6.82 for M2 , M1 and M3 receptors, respectively). In vivo, displays cardioselectivity over tracheal, intestinal and bladder muscarinic receptors; inhibits vagally and agonist-induced bradycardia. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203517 | 123548-16-3 | C27H37N5O2 | 10 mg/50 mg |
- Arecaidine but-2-ynyl ester tosylate
A potent muscarinicagonist, 4.6-fold that is selective for M2 receptors in the atrium versus those in the ileum.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203519 | 499-04-7 | C11H15NO2•C7H8SO3 | 10 mg/50 mg |
- Arecaidine propargyl ester tosylate
A potent muscarinic receptor agonist. Shows some selectivity for cardiac versus ileal M2 receptors.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203520 | 147202-94-6 | C10H13NO2S ·C7H8SO3 | 10 mg/50 mg |
- Atropine Sulfate Monohydrate
A cholinergic receptor antagonist isolated from Atropa belladona L., Datura stramonium L., and other plants of Solanaceae family.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203322 | 5908-99-6 | (C17H23NO3)2 ·H2SO4•H2O | 100 mg |
- Benzoquinonium Dibromide
Nicotinic antagonist, ganglion blocker. Activates single channels but blocks open channels at nicotinic receptors.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203839 | 311-09-1 | C34H50Br2N4O2 | 10 mg/50 mg |
- Benzoylcholine chloride
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-214590 | 2964-09-2 | C12H18ClNO2 | 10 g/50 g |
- Bevonium Methyl Sulfate
An antibacterial used as an anticholinergic, antispasmodic, and brochodilator.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-210914 | 5205-82-3 | C23H31NO7S | 5 mg |
- Biperiden hydrochloride
Muscarinic receptor antagonist that displays some selectivity for the M1 subtype (Ki values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for M1, M4, M3, M2 and M5 receptors respectively). Displays antiparkinsonian activity. Alleviates extrapyramidal symptoms associated with antipsychotic drugs.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203846 | 1235-82-1 | C21H29NO.HCl | 10 mg/50 mg |
- BQCA
Highly selective allosteric potentiator of the M1 muscarinic acetylcholine receptor (mAChR). Reduces the concentration of ACh required to activate M1 up to 129-fold and displays no potentiation, agonism or antagonism activity at other mAChRs at concentrations up to 100µM. Reverses scopolamine-induced memory deficits and increases blood flow to the cerebral cortex in mouse models. M1 activators slow the progression of Alzheimers disease. Induces β-arrestin recruitment to M1. At 100µM, it activated M1 in the absence of ACh to ca. 50% maximal response. At 10µM, it reduced the concentration of ACh required to displace radioligand by 45-fold. In vivo experiments were carried out in mice at 15 or 20mg/kg. The compound is cell permeable, brain penetrant and orally active.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-280627 | n.n. | C18H15NO4 | 10 mg/50 mg |
- Bretylium Tosylate
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-360745 | 61-75-6 | C18H24BrNO3S | 200 mg |
- Carbachol
Shown to be an anti-apoptosis agent also reported to prevent an increase in endothelial cell permeability induced by TNF-α and a decrease in phosphor-ERK1/2.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202092 | 51-83-2 | C6H15ClN2O2 | 100 mg |
- (Carbethoxymethylene)triphenylphosphorane
A phosphorane compound for Wittig olefinations.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-207403 | 1099-45-2 | C22H21O2P | 50 g |
- Chk2 Inhibitor
A potent and selective inhibitor of Chk2 that contains anti-proliferative and anti-inflammatory properties. It has also been shown to target ATP binding pockets of Chk2.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203885 | 724708-21-8 | C15H13N5O2 | 500 µg |
- Chlorisondamine diiodide
A long lasting nicotinic antagonist (IC50 ~ 1.6 mM). Blockade of central nicotinic responses induced by chlorisondamine can persist for several weeks.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203547 | 96750-66-2 | C14H20Cl4N2 ·2I | 10 mg/50 mg |
- Clidinium Bromide
Clidinium Bromide is used as an antiplasmodic and is an anticholinergic.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-207449 | 3485-62-9 | C22H26BrNO3 | 1 g |
- Cytisine
Pyridine-like alkaloid. Nicotine agonist. Ligand for many nAChR subtypes. Potent agonist of α3β4 and α7 nicotinic ACh receptors.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203015 | 485-35-8 | C11H14N2O | 5 mg/25 mg |
- D,L-Trihexyphenidyl, Hydrochloride
Artane is an anticholinergic tertiary amine that can gain access to the CNS. It is used to treat parkinsonism and the extrapyramidal side effects of anti-psychotic drugs. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-211201 | 58947-95-8 | C20H31NO ·HCl | 5 g |
- Darifenacin Hydrobromide
A medication used to treat urinary incontenance where the mechanism of action is blocking the M3 musarinnic acetylcholine receptor.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204708 | 133099-07-7 | C28H30N2O2 ·HBr | 10 mg/25 mg |
- DAU 5884 hydrochloride
Highly potent and selective M3 muscarinic receptor antagonist.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203912 | 131780-47-7 | C17H21N3O3•HCl•xH2O | 10 mg/50 mg |
- (±)-Decanoylcarnitine chloride
Homolog of acetylcarnitine chloride (sc-203495). Intermediate in lipid metabolism.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203914 | 14919-36-9 | C17H34ClNO4 | 50 mg |
- Desformylflustrabromine hydrochloride
A positive allosteric modulator of α4β2 nicotinic acetylcholine receptors (nAChRs) with selectivity over α7; moderate cytotoxicity noted in HCT-116 cell cultures.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-358800 | 474657-72-2 | C16H21BrN2•HCl | 10 mg/50 mg |
- Desoxypeganine hydrochloride
Acetylcholinesterase inhibitor that has been used in the treatment of Alzheimer's dementia.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204712 | 61939-05-7 | C11H12N2 | 25 mg/100 mg |
- Dexetimide·HCl (R 16470)
Dexetimide, also known as R 16470 is a piperidine anticholinergic and a high affinity muscarinic receptor antagonist used to treat neuroleptic-induced parkinsonism.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200166 | 5633-14-7 | C23H26N2O2•HCl | 10 mg |
- Dihydro-β-erythroidine hydrobromide
An acetylcholine receptor antagonist which has been shown to act in a competitive manner. Possesses selectivity for the neuronal α4 subunit, and has been shown to antagonize the effects of nicotine in vivo.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203920 | 29734-68-7 | C16H21NO3 ·HBr | 10 mg/50 mg |
- DMAB-anabaseine dihydrochloride
α7-containing neuronal nicotinic receptor partial agonist and antagonist at α4β2 and other nicotinic receptors. Exhibits specific cognition-enhancing effects; improves rat long-term memory.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203568 | 32013-69-7 | C19H21N3 ·2HCl | 10 mg |
- Edrophonium chloride
An acetycholinesterase inhibitor.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-207610 | 116-38-1 | C10H16ClNO | 250 mg/1 g |
- (±)-Epibatidine
Epibatidine is an analgesic alkaloid isolated from the skin of the poison frog Epipedobates tricolor. It is the most potent nicotinic acetylcholine receptor agonist known. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200177 | 140111-52-0 | C11H13ClN2 | 1 mg/5 mg |
- (+/-)-Epibatidine dihydrochloride hydrate
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-300512 | 162885-01-0 (anhydrous) | C11H13ClN2•2HCl•xH2O | 5 mg |
- Galanthamine
A selective acetylcholinesterase inhibitor that is useful for the treatment of Alzheimerís disease. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-218556 | 357-70-0 | C17H21NO3 | 10 mg |
- Galanthamine Hydrobromide
A competitive and reversible acetylcholinesterase inhibitor, which displays allosteric potentiating effects at nicotinic receptors.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200179 | 1953-04-4 | C17H21NO3··HBr | 25 mg/100 mg |
- Gallamine Triethiodide
M2 muscarinic antagonist with pronounced cardioselectivity. It acts by combining with the cholinergic receptor sites in muscle and competitively blocks the transmitter action of acetylcholine. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200175 | 65-29-2 | C30H60I3N3O3 | 1 g/5 g |
- Himbacine
Himbacine is an alkaloid muscarinic receptor antagonist displaying more potent activity associated with M2 and M4 subtypes.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200181 | 6879-74-9 | C22H35NO2 | 1 mg/5 mg |
- Hydroxytacrine maleate
A cholinesterase inhibitor and a potential Alzheimer’s therapeutic of low toxicity.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200168 | 118909-22-1 | C13H14N2O··C4H4O4 | 200 mg/1 g |
- Ipratropium bromide
Muscarinic antagonist, bronchodilator. N-Isopropyl salt of atropine.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203606 | 22254-24-6 | C20H30BrNO3 | 100 mg |
- Itopride Hydrochloride
A gastroprokinetic benzamide derviative that inhibits acetylcholinesterase reversibly.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204778 | 122892-31-3 | C20H26N2O4 ·HCl | 1 g/5 g |
- J 104129
Potent M3 muscarinic receptor antagonist that displays ~ 120-fold selectivity over M2 receptors (Ki values are 4.2, 19 and 490 nM for human M3, M1 and M2 receptors respectively). Exhibits > 250-fold bronchial selectivity; inhibits ACh-induced bronchoconstriction but not ACh-induced bradycardia (KB values are 3.3 and 170 nM for rat trachea M3 and rat right atria M2 receptors respectively).| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203610 | 244277-89-2 | C24H36N2O2 ·C4H4O4 | 10 mg |
- LY 2365109 hydrochloride
Potent and selective glycine transporter 1 (GlyT1) inhibitor (IC50 values are 15.8 and > 30 000 nM at GlyT1 and GlyT2 respectively). Induces a dose-dependent elevation in CSF levels of glycine, and enhances acetylcholine and dopamine release in the striatum and prefrontal cortex respectively. Profound locomotor and respiratory impairments at higher doses.
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204063 | 868265-28-5 | C22H28ClNO5 | 10 mg/50 mg |
- L-Hyoscyamine
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-295290 | 101-31-5 | C17H23NO3 | 1 g/5 g |
- Lobeline hydrochloride
A potent agonist of the nAChRs. Modulates 86Rb+ efflux. Inhibits dopamine uptake into synaptic vesicles.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203114 | 134-63-4 | C22H27NO2 ·HCl | 50 mg/1 g |
- LY2033298
LY2033298 is an allosteric potentiator that is highly selective for the human M4 mAChR subtype.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-300942 | 886047-13-8 | C13H14ClN3O2S | 5 mg |
- Mecamylamine Hydrochloride
A noncompetitive and nonselective antagonist of nicotinic acetylcholine receptors, that preferentially blocks nicotinic receptors at autonomic ganglia and is able to cross the blood brain barrier.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-205742 | 826-39-1 | C11H21N ·HCl | 5 mg/25 mg |
- Mepenzolate Bromide
Anticholinergic.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-358272 | 76-90-4 | C21H26BrNO3 | 5 g |
- Methyllycaconitine citrate
Potent antagonist for α7-containing neuronal nicotinic receptors (Ki = 1.4 nM). Interacts with α4β2 and α6β2 receptors at concentrations > 40 nM. Attenuates METH-induced neurotoxicity in mouse striatum in vivo.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203632 | 21019-30-7 | C37H50N2O10 ·C6H8O7 | 5 mg/25 mg |
- Methyllycaconitine Perchlorate, Delphinium sp.
Has high affinity (nM range) for a subtype of the neuronal acetylcholine receptor (nAchR) in the brain; exhibits micromolar affinity for muscle acetylcholine receptor and for α-bungarotoxin-insensitive neuronal nAChR.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221938 | n.n. | C37H51ClN2O14 | 5 mg |
- MG 624
a7neuronal nicotinic receptor antagonist. Inhibits a-Bgtx binding to chick a7 and a4b2 subtypes.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204082 | 77257-42-2 | C22H30NOI | 10 mg/50 mg |
- Milameline hydrochloride
Muscarinic receptor agonist that displays roughly equal affinity at all receptor subtypes (Ki values are 2.3, 2.4, 3.6, 3.8 and 4.3 μM for hM1, hM2, hM3, hM4 and hM5 receptors respectively). Cognitive enhancer; reverses spatial memory deficits in rats.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204085 | 139886-32-1 | C8H14N2O•HCl | 10 mg/50 mg |
- MR 16728 hydrochloride
A cetiedil analog that stimulates the release of acetylcholine from synaptosomes.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204099 | 147614-21-9 | C23H36N2O ·HCl | 10 mg/50 mg |
- (±)-Myristoylcarnitine chloride
Homolog of acetylcarnitine chloride. Intermediate in lipid metabolism.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204108 | 14919-38-1 | C21H42ClNO4 | 50 mg |
- N,N,N-Trimethyl-1-(4-trans-stilbenoxy)-2-propylammonium iodide
It is an antagonist of nicotinic acetylcholine receptors.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-301439 | n.n. | C20H26INO | 25 mg |
- NDNI hydriodide
This product is a highly selective α4β2 nicotinic receptor antagonist
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-301459 | 244025-06-7 | C20H36I2N2 | 5 mg |
- Neostigmine Bromide
An acetylcholine esterase inhibitor that has protective effects against gastric carcinogenesis. May provide analgesic effects in neoplasia patients.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204816 | 114-80-7 | C12H19BrN2O2 | 250 mg/1 g |
- (-)-Nicotine ditartrate
Potent agonist of the nicotinic acetylcholine receptor. Stimulates autonomic ganglia and skeletal muscle neuromuscular junctions. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203161 | 65-31-6 | C10H14N2 ·2C4H6O6 | 100 mg |
- Nitrocaramiphen hydrochloride
M1 selective muscarinic antagonist. 71-fold selectivity over M2.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204129 | n.n. | C18H26N2O4.HCl | 10 mg/50 mg |
- NS 1738
Selective a7 nAchR allosteric modulator. a4b2, a3b3 and a1-containing receptors display no substantial activity. In vivo, displays cognitive-enhancing properties.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204136 | 501684-93-1 | C14H9Cl2F3N2O2 | 10 mg/50 mg |
- Obidoxime Chloride
Cholinesterase reactivator.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-212467 | 114-90-9 | C14H16Cl2N4O3 | 1 g |
- (±)-Octanoylcarnitine chloride
Homolog of acetylcarnitine chloride (sc-203495). Acylcarnitines are important intermediates in lipid metabolism. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204143 | 18822-86-1 | C15H30ClNO4 | 50 mg |
- Oxotremorine M
A muscarinic receptor agonist.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203656 | 63939-65-1 | C11H19IN2O | 100 mg |
- Oxotremorine Sesquifumarate
An M2 and M4 Muscarinic acetylcholine receptor agonist. Combinations of oxotremorine and other muscarinic agonists display supra-additive memory enhancement.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200170 | 17360-35-9 | C12H18N2O•1.5C4H4O4 | 100 mg/500 mg |
- Pancuronium dibromide
Nicotine (neuromuscular) antagonist. Skeletal muscle relaxant.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203179 | 15500-66-0 | C35H60Br2N2O4 | 10 mg/50 mg |
- PD 102807
Selective M4 muscarinic receptor antagonist. IC50 values are 91, 6559, 3441, 950 and 7412 nM for human M4, M1, M2, M3, and M5 receptors respectively.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203659 | 23062-91-1 | C23H24N2O4 | 10 mg/50 mg |
- PG-9 maleate
A potent analgesic and nootropic agent. Increases release of acetylcholine.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204184 | n.n. | C17H22BrNO2 ·C4H4O4 | 10 mg/50 mg |
- PHA 568487
Agonist of the α7 nicotinic acetylcholine receptor (Ki values are 44 and 2800 for α7 and 5-HT3 respectively, IC50 values are > 100 μM for α3β4 and α1β1δγ respectively, and % inhibition is < 1 and 5 % for α4β2 and hERG respectively). Orally active and brain penetrant.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204186 | 527680-56-4 | C16H20N2O3 ·C4H4O4 | 10 mg/50 mg |
- Phenserine
Physostigmine analog that inhibits acetylcholinesterase. Inhibits production of Aβ and amyloid precursor protein (APP). Improves morris water maze performance of scopolamine-treated rats.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204188 | 101246-66-6 | C20H23N3O2 | 50 mg |
- Physostigmine hemisulfate
An analogue of Physostigmine.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203661 | 64-47-1 | (C15H21N3O2)2•H2SO4 | 100 mg |
- (+)-Pilocarpine hydrochloride
Cholinergic agonist.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203196 | 54-71-7 | C11H16N2O2.HCl | 1 g |
- Pilocarpine nitrate salt
A nonselective muscarinic acetylcholine receptor agonist, that is used to produce an experimental model of epilepsy.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-250722 | 148-72-1 | C11H16N2O2•HNO3 | 10 g |
- Pirenzepine Dihydrochloride
A selective antagonist for the M1 muscarinic receptor (mAChR) with reported IC50 = 2.51x10-7.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204197 | 29868-97-1 | C19H21N5O2 ·2HCl | 100 mg |
- PNU 120596
A type II positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor (nAChR) located on the somatodendritic membrane of hippocampal interneurons.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203200 | 501925-31-1 | C13H14ClN3O4 | 1 mg/5 mg |
- PNU-282,987
PNU-282,987 is a highly selective agonist for the homomeric α7 nicotinic acetylcholine receptor (α7 nAChR).| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200187 | 123464-89-1 | C14H17ClN2O | 10 mg/50 mg |
- PNU-282987 hydrate
PNU-282,987 is a highly selective agonist for the homomeric α7 nicotinic acetylcholine receptor (α7 nAChR).| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-301554 | 123464-89-1 (anhydrous) | C14H17ClN2O•HCl•xH2O | 10 mg |
- Procyclidine hydrochloride
An atropine-like antispasmodic.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-250777 | 1508-76-5 | C19H29NO ·HCl | 1 g |
- (±)-Propionylcarnitine chloride
Homolog of acetylcarnitine chloride (sc-203495). Acylcarnitines are important intermediates in lipid metabolism.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204864 | 17298-37-2 | C10H20CINO4 | 50 mg |
- Propiverine, Hydrochloride
Used for treatment of urinary incontinence.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-212594 | 54556-98-8 | C23H30ClNO3 | 100 mg |
- R(-)-Quinuclidinyl benzilate methiodide
Nonselective muscarinic acetylcholine receptor antagonist.
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-301655 | n.n. | C22H26INO3 | 2 mg |
- Rivastigmine Hydrogen Tartrate
A parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer’s type and Parkinson's disease.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204883 | 129101-54-8 | C18H28N2O8 | 100 mg/250 mg |
- RJR 2403 oxalate
CNS selective nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki values are 26 and 36000 nM for α4β2 and α7 receptors respectively). Active in vivo. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204884 | 183288-99-5 | C10H14N2 ·C4H4O4 | 10 mg/50 mg |
- RJR 2429 dihydrochloride
Potent nAChR agonist that displays selectivity for α4β2 (Ki = 1 nM) and α1βγδ subtypes (EC50 values are 297 and 55 nM respectively). Induces dopamine release from striatal neurons (EC50 = 2 nM) and inhibits ion flux in thalamic neurons (IC50 = 154 nM). Also putative α3β4 agonist that potentiates catecholamine release.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204237 | 91556-75-1 | C12H16N2 ·2HCl | 10 mg/50 mg |
- S-Butyrylthiocholine Iodide
Chromogenic substrate for cholinesterases. Cleavage is measured colorimetrically at 405 nm.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-286740 | 1866-16-6 | C9H20INOS | 5 g |
- (S)-(+)-Dimethindene maleate
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-361329 | 121367-05-3 | C20H24N2.C4H4O4 | 10 mg/50 mg |
- (-)-Scopolamine hydrobromide
A competitive antagonist of acetylcholine muscarinic receptors, with selectivity for the M1 subtype.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203259 | 114-49-8 | C17H21NO4 ·HBr | 1 g |
- SM-21 maleate
Potent and selective σ2 antagonist with central effects following systemic administration. Increases release of acetylcholine at central muscarinic synapses. Potent analgesic (efficacy comparable to morphine) and nootropic agent.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204289 | 155058-71-2 | C18H24ClNO3•C4H4O4 | 10 mg/50 mg |
- Solifenacin Hydrochloride
A muscarinic M3 receptor antagonist that is used in treatment of urinary incontinence.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-212950 | 180468-39-7 | C23H27ClN2O2 | 10 mg |
- Succinylcholine chloride dihydrate
Cholinergic antagonist which induces a long-lasting depolarization of the acetylcholine neuron membrane.
A neuromuscular blocking agent.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-212965 | 6101-15-1 | C14H30Cl2N2O4•2H2O | 25 g |
- Tacrine·HCl
Shown to be an anticholinesterase that reversibly inhibits acetylcholine esterase. Also has been reported to display hepatotoxicity via inhibition of DNA synthesis in hepatocytes. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200172 | 1684-40-8 | C13H14N2 ·HCl | 1 g/5 g |
- TC 1698 dihydrochloride
Selective nicotinic α7 receptor agonist (EC50 = 440 nM). Displays a weak partial agonist/antagonist activity at β-subunit-containing receptors. Also neuroprotective.
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204324 | 700834-58-8 | C13H18N2.2HCl | 10 mg/50 mg |
- TC 2559 difumarate
Subtype-selective partial agonist for α4β2 nicotinic acetylcholine receptors (EC50 values are 0.18, 12.5, 14.0, > 30, > 100 and > 100 μM for α4β2, α4β4, α2β4, α3β4, α3β2 and α7 receptor subtypes respectively). Displays selectivity for (α4)2(β2)3 receptor stoichiometry and enhanced CNS-PNS selectivity ratio. Attenuates scopolamine-induced cognitive deficits in a step-through passive avoidance task.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203707 | 212332-35-9 | C12H18N2O ·2C4H4O4 | 10 mg/50 mg |
- Telenzepine dihydrochloride
A salt of Telenzepine that is a potent and selective muscarnic receptor antagonist for M1 and M2 receptors.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204332 | 147416-96-4 | C19H24Cl2N4O2S | 10 mg/50 mg |
- Telenzepine dihydrochloride hydrate
A derivative of Telenzepine that is a potent and selective muscarnic receptor antagonist for M1 and M2 receptors.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-251109 | 147416-96-4 (anhydrous) | C19H22N4O2S•2HCl•xH2O | 10 mg/25 mg |
- Tropanyl 2-(4-chlorophenoxy)propionate maleate
Strong analgesic and nootropic agent. Responsible for the increased release of acetylcholine at central muscarinic synapses.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-222373 | n.n. | C17H22ClNO3•C4H4O4 | 10 mg |
- Tropanyl 2-(4-chlorophenylthio)butanoate oxalate
Potent analgesic and nootropic agent. Increases release of acetylcholine at central muscarinic synapses. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-205983 | n.n. | C20H26ClNO6S | 10 mg |
- Tropanyl 2-naphthoxypropionate maleate
Strong analgesic and nootropic agent. Responsible for the increased release of acetylcholine at central muscarinic synapses.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-222374 | n.n. | C25H29NO7 | 10 mg |
- (+)-Tubocurarine chloride pentahydrate
An inhibitor of the acetylcholine receptor.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-216029 | 6989-98-6 | C37H42Cl2N2O6 ·5H2O | 250 mg/1 g |
- (±)-Vesamicol·HCl (AH-5183)
An inhibitor of acetylcholine transport into vesicles. Reduces the storage and subsequent release of acetylcholine into neurons.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200174 | 120447-62-3 | C17H25NO•HCl | 200 mg |
- VU 0238429
A selective positive allosteric modulator of M5 receptors (EC50 values are 1.16, >30 and >30 μM at M5, M1 and M3 receptors respectively). Displays no activity at M2 and M4 receptors. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-301975 | 1160247-92-6 | C17H12F3NO4 | 10 mg/50 mg |
- VU 10010
Selective allosteric potentiator of M4 acetylcholine receptors (EC50 values are 33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively). Binds to an allosteric site on the receptor increasing affinity coupling to G-proteins and for ACh.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204387 | 633283-39-3 | C17H16ClN3OS | 10 mg/50 mg |
- VU 152100
A selective positive allosteric modulator of M4 muscarinic acetylcholine receptors (mAChRs).| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-311554 | n.n. | C18H19N3O2S | 10 mg/50 mg |
- W84 dibromide
One of the first potent allosteric modulators of muscarinic receptors, selective for M2-receptors.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203312 | 21093-51-6 | C32H44Br2N4O4 | 5 mg |
- Xanomeline L-tartrate hydrate
Xanomeline L-tartate is a M1 muscarinic receptor agonist.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-301981 | 131986-45-3 | C14H23N3OS•xC4H6O6•yH2O | 5 mg |
- Xanomeline oxalate
Functionally selective muscarinic M1 receptor agonist which exhibits antipsychotic activity, and improves cognitive deficits and behavioral disturbances in Alzheimer's disease and schizophrenia.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204402 | 141064-23-5 | C14H23N3OS ·C2H2O4 | 10 mg/50 mg |
- Zamifenacin fumarate
Selective M3 muscarinic antagonist receptor (pKi values are 8.52, 7.93, 7.90 and 7.78 for M3, M2, M1 and M4 receptors respectively). Displays higher affinity at ileal M3 receptors (pKi = 9.3) compared to oesophageal and tracheal M3 receptors (pKi values are 8.8 and 8.2 respectively). In vivo, inhibits gastrointestinal motility in the absence of cardiovascular effects.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204416 | 127308-98-9 | C31H33NO7 | 10 mg/50 mg |
|