Chloride Channel Modulators

• 9-AC
  Cl- transport inhibitor with a moderate to strong inhibitory action on PKA activated cardiac IcI.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203483	723-62-6	C15H10O2	100 mg

• DPC
  A potent, non-specific blocker of Cl^– channel and chloride-bicarbonate exchange. Also inhibits cystic fibrosis transmembrane regulator (CFTR) ATPase activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202590	91-40-7	C13H11NO2	1 g

• DCPIB
  Selective blocker of VSAC/ICl, swell in various CV tissues; inhibits glucose-stimulated insulin release. In vitro, reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203913	82749-70-0	C22H28Cl2O4	10 mg/50 mg

• DCEBIO
  Stimulates the secretion of Cl- via activation of hIK1 K⁺ channels and the activation of an apical Cl- conductance. Is more potent than its analog 1-EBIO

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203561	60563-36-2	C9H8Cl2N2O	10 mg/50 mg

• DIDS, Disodium Salt
  Binds covalently and irreversibly to the outer surface of human erythrocyte membranes. Inhibits ATP transport into endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl– uptake (IC₅₀ = 150 nM) in neuroblastoma cells. Has anti-ulcerous properties.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203919	67483-13-0	C16H8Na2N2O6S4	250 mg/25 mg/100 mg

• Fipronil
  A channel blocker that blocks GABA-gated chloride channels and glutamate-activated chloride channels (GluCls).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201546	120068-37-3	C12H4Cl2F6N4OS	20 mg/100 mg

• IAA-94
  A potent mammalian skeletal muscle and epithelial Cl^- channel blocker (K_i=1µM in bovine kidney cortex microsomes).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201544	54197-31-8	C17H18Cl2O4	10 mg/50 mg

• Lonidamine
  An indazole compound that has been reported to inhibit angiogenic-related endothelial cell functions. Also been shown to cause a decrease in proliferation, migration, and morphogenesis of cells.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203115	50264-69-2	C15H10Cl2N2O2	5 mg/25 mg

• 5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB)
  A potent chloride channel blocker. Shown to suppress prostaglandin E2 release.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201542	107254-86-4	C16H16N2O4	10 mg/50 mg

• PG 01
  A cystic fibrosis transmembrane conductance regulator (CFTR) potentiator which is reported to correct gating defects of several CFTR mutants.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-358839	853138-65-5	C28H29N3O2	10 mg/50 mg

• Picrotoxin
  A noncompetitive inhibitor of GABA Cl^--current which affects neuronal firing activity. Shown to increase noradrenaline levels and turnover in the hypothalamus.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202765	124-87-8	C30H34O13	1 g/5 g

• SFK1
  A cell permeable suppressor of FK506 1, which, in high salt media, reverses the inhibition of cell growth by FK506. It interacts with Por1p (YVDAC1) channel protein in the outer mitochondrial membrane. The compound perturbs ion homeostasis and induces hyperpolarization of the inner mitochondrial membrane and mitochondria-dependent cell death with ROS (reactive oxygen species) production in a low NaCl growth media. It also induces expression of calcineurin targeted genes.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-215849	678997-25-6	C23H36N2O2•HCl	10 mg

• Talniflumate
  Calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and release in animal models and cell culture. Possesses anti-inflammatory actions via inhibition of cyclooxygenases and inhibits Cl-/HCO3- exchanger activity. Increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203706	66898-62-2	C21H13F3N2O4	10 mg/50 mg

• VRT-532
  A mutated G551D CFTR corrector. VRT-532 mediates G551D-CFTR by enhancing ATP affinity of the mutant. VRT-532 also potentiates F508del mutated CFTR and works specifically on mutant CFTR rather than other membrane proteins.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-253832	38214-71-0	C16H14N2O	5 mg