Cannabinoids

1,3-bis(4-Bromophenyl)-5-phenyl-2,4-imidazolidinedione
An imidazolidine-2,-4-dione derivative that is an effective and selective inverse agonist of CB cannabinoid receptor.
Katalog # CAS Nummer Summenformel Menge
sc-202872 878533-35-8 C₂₁H₁₄Br₂N₂O₂ 5 mg
2-(14,15-Epoxyeicosatrienoyl) Glycerol
This product is an endogenous central cannabinoid (CB1) receptor agonist and increases DNA synthesis in LLCPKcl4 cells.
Katalog # CAS Nummer Summenformel Menge
sc-205073 848667-56-1 C₂₃H₃₈O₅ 25 µg/50 µg
2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester
A potent, reversible inhibitor of 5-LO, both in cell-free assays (IC₅₀ = 86 nM) and in intact neutrophils (IC₅₀ = 230 nM).
Katalog # CAS Nummer Summenformel Menge
sc-287639 1159576-98-3 C₂₂H₁₈ClNO₃ 1 mg/5 mg
2-Palmitoylglycerol
A fatty acid ester, which increases the ability of 2-arachidonoylglycerol to bind to CB1 and CB2 cannabinoid receptors.
Katalog # CAS Nummer Summenformel Menge
sc-203465 23470-00-0 C₁₉H₃₈O₄ 10 mg
3-decyl-5,5'-diphenyl-2-thioxo-4-imidazolidinone
A reversible competitive inhibitor of FAAH activity exhibiting an IC₅₀value of 1.3 µM. Has no affinity for the human CB1 receptor and acts as a competitive inhibitor of FAAH activity without being hydrolyzed by the enzyme.
Katalog # CAS Nummer Summenformel Menge
sc-204619 875014-22-5 C₂₅H₃₂N₂OS 500 µg/1 mg
7(Z),11(Z)-Pentacosadiene
Unsaturated, long-chain hydrocarbons are found on the cuticles of insects and can act as pheromones. In mature Drosophila melanogaster, certain cuticular hydrocarbons are sexually dimorphic: males synthesize 23- and 25-C monoenes and females produce 27- and 29-C dienes. Each of these lipids plays specific roles in regulating male sexual behavior, with dienes stimulating courtship. 7(Z),11(Z)-Pentacosadiene is a 25-C hydrocarbon that is found in low abundance on cuticles of mature Drosophila females. Depletion of a female-specific elongase (eloF), which leads to an increase in 7(Z),11(Z)-pentacosadiene along with a parallel decrease in 7,11-nonacosadiene, significantly reduces copulation in Drosophila. This raises the possibility that 7(Z),11(Z)-pentacosadiene may act as an anti-aphrodisiac.
Katalog # CAS Nummer Summenformel Menge
sc-291656 127599-39-7 C₂₅H₄₈ 1 mg/5 mg
8-iso Prostaglandin F2α Ethanolamide
Its been reported that anandamide (AEA) can be used directly by cyclooxygenase-2 and specific prostaglandin H2 (PGH2) isomerases to produce ethanolamide congeners of the classical PGs, including PGF2α. PGF2α ethanolamide has also been reported to be biosynthesized by this mechanism when AEA was infused into the lung and liver of fatty acid amide hydrolase-deficient mice. The accumulation of AEA can also lead to isoprostane-type peroxidative decomposition. 8-iso PGF2α ethanolamide is a standard that allows one to distinguish these non-enzymatic decomposition products from “prostamides” that possible have enzymatic origin.
Katalog # CAS Nummer Summenformel Menge
sc-221140 n.n. C₂₂H₃₉NO₅ 100 µg/500 µg
ABN-CBD
Neurobehaviorally inactive cannabinoid that acts as a selective agonist for GPR55 (EC₅₀ values are 2.5, >30 and >30 μM at GPR55, CB1 and CB2 receptors respectively). Increases the phosphorylation of protein kinases in, and migration of, human umbilical vein endothelial cells.
Katalog # CAS Nummer Summenformel Menge
sc-203488 22972-55-0 C₂₁H₃₀O₂ 10 mg
Abnormal Cannabidiol-d3
Contains three deuterium atoms at the terminal methyl position. Intended for use as an internal standard for the quantification of compound by GC- or LC-mass spectrometry. A synthetic regioisomer of cannabidiol that fails to elicit either CB1 or CB2 responsiveness and is without psychotropic activity. Induces endothelium-dependent vasodilation via a CB1/CB2/nitric oxide-independent mechanism. Showed hypotensive activity that could not be antagonized by cannabidiol or SR141716A. Compound is therefore believed to activate a third type of CB receptor, provisionally called the non-CB1/CB2 endocannabinoid receptor. Also acts via these receptors to regulate the migratory activity of murine BV-2 microglial cells, with an EC₅₀ value of 600 nM.
Katalog # CAS Nummer Summenformel Menge
sc-223766 n.n. C₂₁H₃₀D₃O₂ 100 µg/500 µg
ACEA
A compound that can bind to CB1 receptors with a high affinity of K_i=1.4nM and acts as a potent and selective agonist of the CB1 receptors.
Katalog # CAS Nummer Summenformel Menge
sc-202902 220556-69-4 C₂₂H₃₆ClNO 5 mg
Allopregnanolone
Progesterone metabolite devoid of any progestational activity. Acts as a potent ligand of GABA-mediated Cl uptake in synaptosomes more effectively (100- to 1,000-fold) than benzodiazepines or barbituates. In dose-dependent manner, causes a raid increase in Ca²⁺ influx.
Katalog # CAS Nummer Summenformel Menge
sc-203813 516-54-1 C₂₁H₃₄O₂ 10 mg
α-Linolenoyl Ethanolamide
α-Linolenoyl ethanolamide is an endocannabinoid containing α-linolenic acid in place of the arachidonate moiety of AEA. It has been detected in porcine brain, but its relative importance and specific role as a cannabinergic neurotransmitter have not been elucidated.
Katalog # CAS Nummer Summenformel Menge
sc-223763 57086-93-8 C₂₀H₃₅NO₂ 5 mg/10 mg
AM 281
Analog of the cannabinoid receptor (CB) antagonist SR 141716A. Potent CB1 receptor antagonist/inverse agonist (Kⁱ=14nM).
Katalog # CAS Nummer Summenformel Menge
sc-202050 202463-68-1 C₂₁H₁₉Cl₂IN₄O₂ 1 mg/5 mg
AM-251
A ¹²³I radioisotope derivative of the CB₁ cannabinoid receptor inverse agonist SR141716A. Demonstrates a strong affinity (K_i = 7.49 nM) for CB₁. A radioprobe for CB₁-ligand binding studies.
Katalog # CAS Nummer Summenformel Menge
sc-200366 183232-66-8 C₂₂H₂₁Cl₂IN₄O 10 mg/1 mg/50 mg
AM-404
Anandamide is an endocannabinoid transport inhibitor, which does not activate cannabinoid receptors or inhibit anandamide amidase.
Katalog # CAS Nummer Summenformel Menge
sc-200363 198022-70-7 C₂₆H₃₇NO₂ 10 mg/50 mg
AM-630
A potentially useful cannabinoid receptor antagonist selective for CB1 and CB2.
Katalog # CAS Nummer Summenformel Menge
sc-200365 164178-33-0 C₂₃H₂₅IN₂O₃ 10 mg
Arachidonamide (20:4, n-6)
A weak cannabinoid CB1 and CB2 agonist 1.
Katalog # CAS Nummer Summenformel Menge
sc-221258 85146-53-8 C₂₀H₃₃NO 10 mg/50 mg
Arachidonoyl 2'-fluoroethylamide
CB1 receptor agonist (CB1: K_i=26.7nM; CB2: K_i=908nM).
Katalog # CAS Nummer Summenformel Menge
sc-202469 166100-37-4 C₂₂H₃₆NOF 5 mg
Arachidonoyl p-Nitroaniline
A relatively unselective enzyme that accepts a variety of amide head groups other than the ethanolamine of its nominal endogenous substrate AEA.
Katalog # CAS Nummer Summenformel Menge
sc-205211 119520-58-0 C₂₆H₃₆N₂O₃ 1 g/10 g
Arachidonoyl-1-thio-Glycerol
2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the central cannabinoid (CB1) receptor. It is present at relatively high levels in the central nervous system and is the most abundant molecular species of monoacylglycerol found in rat brain. Monoacylglycerol lipase (MGL) hydrolyzes 2-AG to arachidonic acid and glycerol, thereby terminating its biological actions. Arachidonoyl-1-thio-glycerol is a thioester substrate analog of 2-AG that can be utilized for the measurement of MGL activity. Hydrolysis of the thioester bond by MGL generates a free thiol that reacts rapidly with the chromogenic reagent DTNB (Ellman’s reagent) resulting a yellow product with an absorbance maximum at 412 nm.
Katalog # CAS Nummer Summenformel Menge
sc-221265 n.n. C₂₃H₃₈O₃S 1 mg/5 mg
Arachidonoyl-AMC
A fluorogenic substrate for fatty acid amide hydrolase (FAAH)1. This substrate is the basis for a simple, selective and sensitive assay for FAAH which is amenable to high-throughput screening.
Katalog # CAS Nummer Summenformel Menge
sc-223784 n.n. C₃₀H₃₉NO₃ 5 mg/25 mg
Arachidonoyl-N-methyl amide
Binds to the human central cannabinoid receptor with a K_i of 60 nM; inhibits rat glial gap junction cell-cell communication.
Katalog # CAS Nummer Summenformel Menge
sc-205212 156910-29-1 C₂₁H₃₅NO 5 mg/10 mg
Arachidonylcyclopropylamide (ACPA)
ACPA is an N-arachidonylethanolamine analog and a selective cannabinoid CB1 receptor.
Katalog # CAS Nummer Summenformel Menge
sc-200795 229021-64-1 C₂₃H₃₇NO 10 mg/50 mg
AVE-1625
The central cannabinoid (CB1) receptor is a G protein-coupled receptor that is widespread in the central nervous system and several peripheral tissues and binds the active component of cannabis, Δ9-tetrahydrocannabinol. Signaling through the CB1 receptor is involved in attentional and working memory deficits as well as obesity. AVE-1625 is a selective, highly potent antagonist for the CB1 receptor with Ki values of 0.16-0.44 nM. At 1-3 mg/kg, AVE-1625 significantly enhances the performance of rodents in working memory tasks. At 30 mg/kg, AVE-1625 reduces caloric intake by more than 50% of controls, reduces hepatic glycogen levels in rodents and significantly increases lipolysis from fat tissues.
Katalog # CAS Nummer Summenformel Menge
sc-221277 358970-97-5 C₂₃H₂₀Cl₂F₂N₂O₂S 1 mg/5 mg
Bay 59-3074
Katalog # CAS Nummer Summenformel Menge
sc-361118 406205-74-1 C₁₈H₁₃F₆NO₄S 10 mg/50 mg
BML-190
An indomethacin morpholinylamide which functions as a selective inverse agonist of the human cannabinoid CB2 receptor.
Katalog # CAS Nummer Summenformel Menge
sc-203533 2854-32-2 C₂₃H₂₃ClN₂O₄ 10 mg/50 mg
CAY10448
An iodinated nonivamide, a potent capsaicin receptor antagonist with an IC₅₀ of approximately 10 nM.
Katalog # CAS Nummer Summenformel Menge
sc-223862 n.n. C₁₈H₂₈INO₃ 1 mg/5 mg
CB 13
Potent, orally active CB1/CB2 receptor agonist with limited brain penetration (EC₅₀ values are 6.1 and 27.9 nM for CB1 and CB2 receptors respectively).
Katalog # CAS Nummer Summenformel Menge
sc-203870 432047-72-8 C₂₆H₂₄O₂ 10 mg/50 mg
CB 65
Katalog # CAS Nummer Summenformel Menge
sc-361134 n.n. C₂₂H₂₈ClN₃O₃ 10 mg/50 mg
CB-52
A stable analog of Δ9-tetrahydrocannabinol (THC) and anandamide (AEA) which exhibits high affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptor with K_i values of 210 and 30 nM, respectively. This compound behaves primarily as a CB1 receptor partial agonist and a CB2 receptor neutral antagonist in vitro.
Katalog # CAS Nummer Summenformel Menge
sc-221404 n.n. C₂₆H₄₃NO₃ 1 mg/5 mg
CB-86
A resorcinol-anandamide hybrid compound that acts as a partial agonist for the central cannabinoid (CB₁) receptor and a neutral antagonist for the peripheral cannabinoid (CB₂) receptor.
Katalog # CAS Nummer Summenformel Menge
sc-293987 1150586-64-3 C₂₆H₄₃NO₃ 1 mg/5 mg
CB-25
CB-25 is a stable analog of anandamide (AEA) and Δ9-tetrahydrocannabinol (THC). It exhibits high affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with K_i values of 5.2 and 13 nM, respectively. CB-25 behaves as an inverse agonist for the CB1 receptor as assessed in a cyclic AMP (cAMP) functional assay.
Katalog # CAS Nummer Summenformel Menge
sc-204675 869376-63-6 C₂₅H₄₁NO₃ 1 mg/5 mg
Copper(II) Protoporphyrin IX (free acid)
A negative control for the heme oxygenase inhibitor, zinc protoporphyrin IX.
Katalog # CAS Nummer Summenformel Menge
sc-205935 n.n. C₃₄H₃₂CuN₄O₄ 25 mg
CP-55,940
A cannabimimetic and potent cannabinoid receptor agonist. Demonstrates similar affinity at CB1 and CB2 (CB1 K_i=0.58 nM, CB2 K_i=0.69 nM).
Katalog # CAS Nummer Summenformel Menge
sc-200359 83002-04-4 C₂₄H₄₀O₃ 5 mg/25 mg
CP 945598 hydrochloride
Katalog # CAS Nummer Summenformel Menge
sc-361159 686347-12-6 C₂₅H₂₅Cl₂N₇O•HCl 10 mg/50 mg
DEA
Potent endocannabinoid (anandamide analog) that activates CB1 receptors in microglia and binds to rat synaptosomal membranes.
Katalog # CAS Nummer Summenformel Menge
sc-203024 150314-35-5 C₂₄H₄₁NO₂ 5 mg
Decanoyl-p-nitroanilide
A fatty acid amide used as a probe for FAAH activity. Processing by FAAH releases an equivalent of p-nitroaniline which can be assayed with UV-Vis (382 nm, ε = 13500 M^-1cm^-1).
Katalog # CAS Nummer Summenformel Menge
sc-201429 72298-63-6 C₁₆H₂₄N₂O₃ 20 mg/100 mg
Dihomo-γ-linolenylethanolamide
Endocannabinoid. Binds to recombinant human CB1 (K_i=857nM) and CB2 receptor (K_i=598nM). Also inhibits adenylyl cyclase (IC₅₀=109nM).
Katalog # CAS Nummer Summenformel Menge
sc-202137 150314-34-4 C₂₂H₃₉NO₂ 5 mg
Docosahexaenoyl Ethanolamide
Docosahexaenoic Acid (DHA) is an essential fatty acid and the most abundant ω-3 fatty acid in neural tissues, particularly in the retina and brain. Docosahexaenoyl ethanolamide (DHEA) is an ethanolamine amide of DHA that has been detected in both retina and brain at concentrations similar to those for arachidonoyl ethanolamide (AEA). A 9.5 fold increase of DHEA was observed in brain lipid extracts from piglets on a DHA-supplemented diet compared to a DHA-free control diet. DHEA binds rat brain CB1 receptor with a K_ι of 324 nM, which is about 10-fold higher than the K_ι for AEA. DHEA inhibits shaker-related voltage-gated potassium channels in the brain slightly better than AEA, with an IC₅₀ of 1.5 µM.
Katalog # CAS Nummer Summenformel Menge
sc-221563 162758-94-3 C₂₄H₃₇NO₂ 5 mg/10 mg
Ethyl Ferulate
Induces heme oxygenase-1 and protects rat neurons against oxidative stress. Protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity.
Katalog # CAS Nummer Summenformel Menge
sc-200823 4046-02-0 C₁₂H₁₄O₄ 100 mg
Fluprostenol serinol amide
A stable analog of PGF2α 2-glyceryl ester that has much greater stability. The biological activity of Flu-SA has not yet been determined.
Katalog # CAS Nummer Summenformel Menge
sc-221620 n.n. C₂₆H₃₆F₃NO₇ 1 mg/5 mg
Glycerophospho-N-Oleoyl Ethanolamine
N-Acylated ethanolamines (NAE) are naturally-occurring lipids with diverse bioactivities. For example, arachidonoyl ethanolamide (AEA) is an endogenous cannabinoid neurotransmitter that evokes cellular responses by activating the cannabinoid receptors, peripheral cannabinoid (CB2) and central cannabinoid (CB1). The different types of NAE are derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1 (GDE1). Glycerophospho-N-oleoyl ethanolamine is the precursor of oleoyl ethanolamide (OEA). OEA is an potent, endogenous agonist for PPARα, exhibiting an EC₅₀ value of 120 nM in a transactivation assay. Systemic administration of OEA suppresses food intake and reduces weight gain in rats (10 mg/kg intraperitoneally) and PPARα wild-type mice, but not in PPARα knockout mice. Like AEA, OEA is metabolized by fatty acid amide hydrolase (FAAH).
Katalog # CAS Nummer Summenformel Menge
sc-224008 201738-24-1 C₂₃H₄₆NO₇P 1 mg/5 mg
Glycerophospho-N-Palmitoyl Ethanolamine
N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities.
Katalog # CAS Nummer Summenformel Menge
sc-224009 100575-09-5 C₂₁H₄₄NO₇P 1 mg/5 mg
GP 1a
Highly selective CB2 agonist receptor; Ki values are 0.037 and 363 nM for CB2 and CB1 receptors respectively. Increases P-ERK1/2 expression in HL-60 cells in vitro.
Katalog # CAS Nummer Summenformel Menge
sc-203980 n.n. C₂₃H₂₂Cl₂N₄O 10 mg/50 mg
GP 2A
Selective CB2 receptor agonist; Ki values are 7.6 and 900 nM for CB2 and CB1 receptors respectively. Increases P-ERK1/2 expression in HL-60 cells in vitro.
Katalog # CAS Nummer Summenformel Menge
sc-203588 919077-81-9 C₂₄H₂₃Cl₂N₃O 10 mg/50 mg
GW-405833
GW-405833 binds to both rat and human CB2 receptors where it acts as a partial agonist.
Katalog # CAS Nummer Summenformel Menge
sc-200373 180002-83-9 C₂₃H₂₄Cl₂N₂O₃ 10 mg/50 mg
GW 842166X
A CB2 receptor agonist with ED50 values of 91 and 63 nM in rat and human, respectively.2 When administered orally to rats in the Freund’s complete adjuvant (FCA) model of inflammatory pain, GW 842166X is highly potent with an ED50 value of 0.1 mg/kg and full reversal of hyperalgesia at 0.3 mg/kg.2
Katalog # CAS Nummer Summenformel Menge
sc-205338 666260-75-9 C₁₈H₁₇Cl₂F₃N₄O₂ 1 mg/5 mg
HU-331
A hydroxylquinone cannabidiol analog that exhibits potent antineoplastic activity on a variety of human cancer cell lines.
Katalog # CAS Nummer Summenformel Menge
sc-205345 137252-25-6 C₂₁H₂₈O₃ 500 µg/5 mg
JNJ 1661010
Selective and reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC₅₀ = 12nM). Brain penetrant and active in vivo.
Katalog # CAS Nummer Summenformel Menge
sc-204023 681136-29-8 C₁₉H₁₉N₅OS 10 mg/50 mg
JTE 907
Highly selective cannabinoid CB2 receptor inverse agonist. Binds with high affinity to rat, mouse and human CB2 receptors (Ki values are 0.38, 1.55 and 35.9 nM respectively). Produces anti-inflammatory effects in vivo.
Katalog # CAS Nummer Summenformel Menge
sc-203616 282089-49-0 C₂₄H₂₆N₂O₆ 10 mg/50 mg
L-759633
High affinity, selective CB2 receptor agonist. Potently inhibits forskolin-stimulated cAMP production via CB2 receptors expressed in CHO cells.
Katalog # CAS Nummer Summenformel Menge
sc-203438 174627-50-0 C₂₆H₄₀O₂ 10 mg
Leelamine HCl
A weak agonist of the CB1 receptor. Inhibits PDK activity.
Katalog # CAS Nummer Summenformel Menge
sc-200375 1446-61-3 C₂₀H₃₁N··HCl 10 mg/50 mg
Linoleamide
Unsaturated analog of endogenous sleep-inducing lipid.
Katalog # CAS Nummer Summenformel Menge
sc-221852 n.n. C₁₈H₃₃NO 10 mg/50 mg
Linoleylethanolamide
Endocannabinoid. Does also bind to TRPV1 (K_i=5.60µM).
Katalog # CAS Nummer Summenformel Menge
sc-203107 68171-52-8 C₂₀H₃₇NO₂ 10 mg
LY-320135
Potent and selective Canniboid CB1 receptor antagonist/inverse agonist. Selective (~70 fold) over Canniboid CB2 receptors.
Katalog # CAS Nummer Summenformel Menge
sc-204066 176977-56-3 C₂₄H₁₇NO₄•xH₂O 10 mg/50 mg
MAFP
An irreversible inhibitor of cytosolic phospholipase As that also potently inhibits anandamide amidohydrolase and phosphorylates arachidonyl binding sites.
Katalog # CAS Nummer Summenformel Menge
sc-203440 188404-10-6 C₂₁H₃₆FO₂P 5 mg
MDA 19
Katalog # CAS Nummer Summenformel Menge
sc-358804 1048973-47-2 C₂₁H₂₃N₃O₂ 1mg/5mg
Mead acid ethanolamide
A cannabinoid CB1 and CB2 agonist equipotent with anandamide1.
Katalog # CAS Nummer Summenformel Menge
sc-202704 169232-04-6 C₂₂H₃₉NO₂ 1 mg/10 mg
MJ 15
Katalog # CAS Nummer Summenformel Menge
sc-361252 944154-76-1 C₂₃H₁₇Cl₃N₄O 10 mg/50 mg
N-(3-hydroxyphenyl)-Arachidonoyl amide
An analog of AM404, which is a selective inhibitor of carrier-mediated transport of AEA. 3-HPA is metabolized by both COX-1 and COX-2 and was found to selectively and irreversibly inhibit COX-2 with an IC₅₀ value of 2 µM.
Katalog # CAS Nummer Summenformel Menge
sc-221969 183718-75-4 C₂₆H₃₇NO₂ 5 mg/10 mg
N-Arachidonoyl glycine
Katalog # CAS Nummer Summenformel Menge
sc-362169 179113-91-8 C₂₂H₃₅NO₃ 5 mg
N-Arachidonoyl glycine (solution in ethanol)
Endogenous anandamide-like compound. Lacks affinity for CB1 receptors (Ki>10µM), TRPV1 (EC₅₀>10µM) and anandamide uptake (IC5₅₀>50µM), but inhibits fatty acid amide hydrolase (FAAH) (IC₅₀=8.5µM-50µM, depending on cell type and species).
Katalog # CAS Nummer Summenformel Menge
sc-203149 179113-91-8 C₂₂H₃₅NO₃ 5 mg
N-Arachidonoyl phosphatidylethanolamine
N-arachidonoyl phosphatidylethanolamine (NAPE) is a precursor in anandamide (AEA) biosynthesis via multiple pathways. NAPE can be cleaved by a phospholipase D yielding phosphatidic acid and AEA. On the other hand, in macrophages NAPE is cleaved by a phospholipase C yielding phosphoanandamide (pAEA). A phosphatase, PTPN22 is one enzyme that cleaves pAEA leading to the generation of anandamide. Another pathway proceeds via double deacylation of NAPE generating glycerophospho-NAE. Phosphodiesterase-mediated cleavage of this intermediate yields anandamide.
Katalog # CAS Nummer Summenformel Menge
sc-221989 n.n. C₅₇H₁₀₄NO₄P 1 mg/5 mg
N-Arachidonoyl-(L)-alanine (NA-Ala)
One member of a new class of lipoamino acids related to anandamide identified in bovine brain.
Katalog # CAS Nummer Summenformel Menge
sc-221991 n.n. C₂₃H₃₇NO₃ 5 mg/25 mg
N-Arachidonoyl-GABA (NA-GABA)
One member of a new class of lipoamino acids related to anandamide identified in bovine brain1. Displays analgesic activity1,2.
Katalog # CAS Nummer Summenformel Menge
sc-221992 128201-89-8 C₂₄H₃₉NO₃ 5 mg/25 mg
N-Arachidonoyl-L-serine
Endocannabinoid-like brain constituent with similar biological profile to abnormal cannabidiol. Binds weakly to CB1 and CB2 receptors and TRPV1. Produces endothelium-dependent vasodilation.
Katalog # CAS Nummer Summenformel Menge
sc-202718 187224-29-9 C₂₃H₃₇NO₄ 10 mg
N-Linoleoylglycine
Possible endogenous LA metabolite and 18:2 anandamide metabolite. May display antinflamatory activity.
Katalog # CAS Nummer Summenformel Menge
sc-205761 2764-03-6 C₂₀H₃₅NO₃ 5 mg/25 mg
N-Oleoyl-L-serine
N-Oleoylserine was isolated from mouse trabecular bone and brain and was determined to be the L-isomer. It was shown to promote the proliferation and growth of MC3T3 E1 osteoblasts at 10-11M via a pertusis toxin-sensitive mechanism and transiently induced ERK1/2 phosphorylation. It inhibited osteoclast formation in vitro and in an ovariectomy-induced bone loss model, it induced complete rescue after 12 weeks (5mg/kg)1.
Katalog # CAS Nummer Summenformel Menge
sc-222013 n.n. C₂₁H₃₉NO₄ 5 mg/25 mg
NESS 0327
NESS 0327 is an extremely potent cannabinoid receptor antagonist with high selectivity for the CB1 receptor compared to the CB2 receptor with K_i values of 0.35 pM and 21 nM, respectively. It is a much more potent antagonist and more selective for the CB1 receptor compared to SR 141716A. At nM concentrations NESS 0327 competitively inhibits the binding of the synthetic CB agonist WIN 55,212-2 in isolated rat cerebella membranes and murine vas deferens. Unlike SR 141716A, NESS 0327 at higher doses does not act as a CB1 receptor inverse agonist and does not produce any physiological effects of its own.
Katalog # CAS Nummer Summenformel Menge
sc-222054 494844-07-4 C₂₄H₂₃Cl₃N₄O 1 mg/5 mg
NS309
A Ca²⁺ -activated IK/SK potassium channel activator.
Katalog # CAS Nummer Summenformel Menge
sc-253202 18711-16-5 C₈H₄Cl₂N₂O₂ 5 mg
O-1602
An analog of cannabidiol and activator of the novel endocannabinoid receptor GRP55. Vasodilation is produced independent of GRP55 activation and independent of the CB1/CB2 receptors.
Katalog # CAS Nummer Summenformel Menge
sc-202745 317321-41-8 C₁₇H₂₂O₂ 1 mg/5 mg
O-1821
O-1821 is a cannabidiol analog with close structural similarity to O-1918 which is a selective antagonist of abnormal cannabidiol at the non-CB1/CB2 endothelial receptor.2 O-1918 does not bind to CB1 or CB2 receptors at concentrations up to 30 µM and inhibits the vasorelaxant effects of abnormal cannabidiol in vitro and in whole animals.2 The biological activity of O-1821 has not been reported.
Katalog # CAS Nummer Summenformel Menge
sc-205417 35482-50-9 C₁₇H₂₂O₂ 1 mg/5 mg
O-1918
Analog of cannabidiol. Antagonist of the endothelial non-CB1/CB2 cannabinoid receptor. Induces endothelium-dependent vasodilation via a CB1/CB2/nitric oxide-independent mechanism.
Katalog # CAS Nummer Summenformel Menge
sc-202746 536697-79-7 C₁₉H₂₆O₂ 1 mg/5 mg
O-2093
Katalog # CAS Nummer Summenformel Menge
sc-361283 n.n. C₃₄H₄₃Cl₂NO₃ 5 mg/25 mg
O-Arachidonoyl Glycidol
An endogenous ligand that binds to both central cannabinoid and peripheral cannabinoid receptors; inhibits fatty acid amide hydrolase-catalyzed hydrolysis of arachidonoyl ethanolamide.
Katalog # CAS Nummer Summenformel Menge
sc-222087 439146-24-4 C₂₃H₃₆O₃ 5 mg/10 mg
Oleoyl Ethanolamide-d2
Contains two deuterium atoms at the 11 position. It is intended for use as an internal standard for the quantification of OEA by GC- or LC-mass spectrometry.
Katalog # CAS Nummer Summenformel Menge
sc-222098 111-58-0 (unlabeled) C₂₀H₃₇D₂NO₂ 100 µg/500 µg
Oleoyl Ethanolamide-d4
Oleoyl ethanolamide (OEA) is an analog of the endocannabinoid AEA found in brain tissue and in chocolate. It is one of the long chain fatty acid ethanolamides that accumulates rapidly in infarcted tissue but its biosynthesis is reduced in the intestine of rats following food deprivation. OEA is an endogenous, potent agonist for PPARα, exhibiting an EC50 value of 120 nM in a transactivation assay. Systemic administration of OEA suppresses food intake and reduces weight gain in rats (10 mg/kg intraperitoneally) and PPARα wild-type mice, but not in PPARα knockout mice. These data indicate that OEA regulates food intake by a PPARα-mediated mechanism.
Katalog # CAS Nummer Summenformel Menge
sc-295976 n.n. C₂₀H₃₅D₄NO₂ 100 µg/500 µg
Palmitoyl Ethanolamide-d5
A labeled form of an endogenous cannabinoid found in brain, liver, and other mammalian tissues.
Katalog # CAS Nummer Summenformel Menge
sc-296022 n.n. C₁₈H₃₂D₅NO₂ 500 µg/1 mg
Palmitoyl-N-isopropylamide
An inhibitor of the FAAH (fatty acid amide hydrolase). Palmitoyl-N-isopropylamide functions similarly to AM-404 (sc-200363) in inhibiting the formation of [3H]-ethanolamine from [3H]-AEA.
Katalog # CAS Nummer Summenformel Menge
sc-203177 189939-61-5 C₁₉H₃₉NO 5 mg
Palmitoylethanolamide
This product is an endogenous cannabinoid. It is a weak ligand of the cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptors.
Katalog # CAS Nummer Summenformel Menge
sc-202754 544-31-0 C₁₈H₃₇NO₂ 10 mg/50 mg
Petromyzonol
A tetrahydroxy stearol which serves as the primary spawning pheromone in adult sea lamprey.
Katalog # CAS Nummer Summenformel Menge
sc-205430 28979-29-5 C₂₄H₄₂O₄ 1 mg/5 mg
PF 750
Irreversible fatty acid amide hydrolase (FAAH) inhibitor (IC₅₀ = 16.2 nM) that displays no activity at a range of other serine hydrolases. Orally active and selectively inhibits FAAH within the central nervous system.
Katalog # CAS Nummer Summenformel Menge
sc-204181 959151-50-9 C₂₂H₂₃N₃O 10 mg/50 mg
PF 514273
Katalog # CAS Nummer Summenformel Menge
sc-361289 851728-60-4 C₂₁H₁₇Cl₂F₂N₃O₂ 10 mg/50 mg
PF-622
Is a potent, irreversible, time-dependent FAAH inhibitor with IC₅₀ values 0.99 and 0.033 µM when preincubated with human recombinant FAAH for 5 and 60 minutes, respectively. Activity-based profiling of various human and murine tissue proteome samples showed that it is highly selective for FAAH relative to other serine hydrolases, showing no discernable off-site activity up to 500 µM.
Katalog # CAS Nummer Summenformel Menge
sc-205431 898235-65-9 C₂₁H₂₂N₄O 1 mg/5 mg
Pravadoline
A cannabimimetic aminoalkylindole. Cannabinoid receptor agonist. Inhibits COX activity.
Katalog # CAS Nummer Summenformel Menge
sc-200369 92623-83-1 C₂₃H₂₆N₂O₃ 5 mg/25 mg
(R)-Methanandamide
A derivative of Anandamide with higher affinity at the CB₁ receptor (K_i = 20 nM) than Anandamide itself (K_i =78 nM). Relatively stable to aminopeptidase hydrolysis.
Katalog # CAS Nummer Summenformel Menge
sc-200792 157182-49-5 C₂₃H₃₉NO₂ 5 mg/25 mg
Rimonabant
Selective central cannabinoid (CB1) receptor inverse agonist used as an appetite suppressant and anti-obesity drug.
Katalog # CAS Nummer Summenformel Menge
sc-205491 168273-06-1 C₂₂H₂₁Cl₃N₄O 5 mg/10 mg
(±)-SLV 319
(±)-SLV 319 is the mixture of the CB1 receptor antagonist SLV 319 and its distomer, SLV 319 (+)-enantiomer. SLV 319 is a potent and selective CB1 receptor antagonist with Ki values of 7.8 and 7,943 nM for CB1 and CB2, respectively. SLV 319 is less lipophilic and therefore more water soluble than other known CB1 receptor ligands.
Katalog # CAS Nummer Summenformel Menge
sc-222317 362519-49-1 C₂₃H₂₀Cl₂N₄O₂S 1 mg/5 mg
(S)-SLV 319
Central cannabinoid receptor antagonists may have potential in the treatment of a number of diseases such as neuro-inflammatory disorders, cognitive disorders, septic shock, obesity, psychosis, addiction, and gastrointestinal disorders. (S)-SLV 319 is a strong and selective CB1 receptor antagonist with Ki values of 7.8 and 7,943 nM for CB1 and CB2, respectively. (S)-SLV 319 is less lipophilic and therefore more water soluble than other known CB1 receptor ligands.
Katalog # CAS Nummer Summenformel Menge
sc-222285 464213-10-3 C₂₃H₂₀Cl₂N₄O₂S 1 mg/5 mg
SER 601
A potent and selective CB2 receptor agonist (Ki values are 6.3 nM and 1.2 μM for CB2 and CB1 receptors respectively). Has been shown to display analgesic activity in the formalin test in mice.
Katalog # CAS Nummer Summenformel Menge
sc-296379 n.n. C₂₈H₃₈N₂O₂ 10 mg/50 mg
RVD-Hpα
Katalog # CAS Nummer Summenformel Menge
sc-361323 n.n. C₆₅H₁₀₅N₁₉O₁₇ 1 mg
SR 144528
A selective peripheral cannabinoid receptor inverse agonist; antagonizes the inhibitory effects of CP 55,940.
Katalog # CAS Nummer Summenformel Menge
sc-224292 192703-06-3 C₂₉H₃₄ClN₃O 5 mg/10 mg
Tocrifluor T1117
Katalog # CAS Nummer Summenformel Menge
sc-361385 n.n. C₅₆H₅₃Cl₂N₇O₅ 100 µg
trans-EKODE-(E)-Ib
During oxidative stress, the abundant unsaturated fatty acid linoleic acid undergoes lipid peroxidation to produce α,β-unsaturated epoxy-keto-octadecenoic acids (EKODEs). Nonenzymatic autooxidation of linoleic acid generates six major EKODE isomers, which differ from one another in the positioning and the orientation of the epoxy group relative to the keto moiety. trans-EKODE-(E)-Ib is a biologically active peroxidation product of linoleic acid that is characterized, structurally, by having a trans carbon-carbon double bond between the 9-keto and 12,13-epoxy groups. It activates an antioxidant response element (ARE) in neuronal cells and induces the expression of ARE-regulated cytoprotective genes like NQO1. This EKODE also stimulates the synthesis of aldosterone and corticosterone in adrenal cells when supplied at 1-5 μM. This effect appears to be mediated by a rise in intracellular calcium.
Katalog # CAS Nummer Summenformel Menge
sc-296585 478931-82-7 C₁₈H₃₀O₄ 25 µg/50 µg
UCM 707
Potent and selective anandamide uptake inhibitor. Potentiates hypokinetic and antinociceptive effects of anandamide in vivo.
Katalog # CAS Nummer Summenformel Menge
sc-203308 390824-20-1 C₂₅H₃₇NO₂ 5 mg
URB447
URB447 is a mixed central cannabinoid (CB1) receptor antagonist/peripheral cannabinoid (CB2) receptor agonist with IC₅₀ values of 313 and 41 nM, respectively. At 20 mg/kg delivered intraperitoneally to ob/ob mice and Swiss mice, URB447 reduces food intake and body-weight gain with an efficacy comparable to rimonabant,1 which is an inverse agonist for the CB1. Marketed as an anti-obesity drug and appetite suppressant, rimonabant was subsequently suspended from distribution due to serious psychiatric side effects attributed to its indiscriminate activity on CB1 receptors in the central nervous system (CNS). Unlike rimonabant, URB447 does not penetrate the blood brain barrier (to antagonize CB1 receptors in the CNS); instead, it appears to selectively block peripheral CB1 receptors such as those located in the gastrointestinal tract.
Katalog # CAS Nummer Summenformel Menge
sc-224347 1132922-57-6 C₂₅H₂₁ClN₂O 5 mg/10 mg
VDM-11
A selective inhibitor of the anandamide membrane transporter, blocking reuptake of the endocannabinoid anandamide. Shows no agonism of the TRPV1 receptor.
Katalog # CAS Nummer Summenformel Menge
sc-200371 313998-81-1 C₂₇H₃₉NO₂ 10 mg/50 mg
Virodhamine
Endogenous cannabinoid receptor mixed antagonist/agonist found in higher concentrations peripherally than anandamide. Full agonist at GPR55 and CB2 and partial antagonist/agonist at CB1 (EC50 values are 12, 381 and 2920 nM at GPR55, CB2 and CB1 receptors respectively). Induces hypothermia in vivo.
Katalog # CAS Nummer Summenformel Menge
sc-204383 287937-12-6 C₂₂H₃₇NO₂ 5 mg/25 mg
Virodhamine hydrochloride
Partial agonist with in vivo antagonist activity at the CB1 receptor (EC₅₀=1.9µM; 61% efficacy), full agonist for the CB2 receptor (100% efficacy).
Katalog # CAS Nummer Summenformel Menge
sc-202853 443129-35-9 C₂₂H₃₇NO₂•HCl 5 mg
WWL70
A selective inhibitor of α/β-Hydrolase domain 6.1
Katalog # CAS Nummer Summenformel Menge
sc-222420 947669-91-2 C₂₇H₂₃N₃O₃ 1 mg/5 mg