Apoptosis Inhibitors

7,8-dichloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Casein kinase 2 (CK2) is a threonine/serine-selective protein kinase involved in many signal transduction pathways. CK2 is known to negatively regulate apoptosis and its activity is increased in many tumors and proliferating tissues, which lends promise as an anti-cancer drug target. This chemical inhibits CK2 with an IC₅₀ value of 0.8 µM.
Katalog # CAS Nummer Summenformel Menge
sc-223742 300675-28-9 C₁₀H₅Cl₂NO₃ 1 mg/5 mg
7-nitro-10-octyl-3-phenyl-pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione
An antagonist of the interaction between survivin and the apoptosis-promoting protein Smac/Diablo, exhibiting an IC₅₀ value of 2.2 µM; inhibits the interaction of survivin with INCENP less effectively with an IC₅₀ value of 20 µM; cell-permeable and sensitizes cells to the induction of apoptosis by doxorubicin.
Katalog # CAS Nummer Summenformel Menge
sc-352980 137346-42-0 C₂₅H₂₆N₄O₄ 1 mg/5 mg
AG 490, m-CF3
A cell-permeable, m-trifluoromethyl derivative of AG 490 that displays apoptotic and antiproliferative properties. Inhibits IL-7-induced JAK3 tyrosine phosphorylation in 2E8 cells in vitro and significantly decreases lymph node cellularity in a murine B and T cell lymphoma model in vivo.
Katalog # CAS Nummer Summenformel Menge
sc-221221 581797-29-7 C₁₈H₁₃F₃N₂O₃ 10 mg
Apoptosis Inhibitor
Cell-permeable inhibitor of apoptosis induction. Does not directly inhibit caspase-3, but effects are attributable to the inhibition of caspase-3 activation.
Katalog # CAS Nummer Summenformel Menge
sc-205595 54135-60-3 C₁₃H₁₆O₄ 10 mg
Apoptosis Inhibitor II, NS3694
A cell-permeable diarylurea compound that suppresses the formation of the apoptosome Apaf-1.
Katalog # CAS Nummer Summenformel Menge
sc-203823 426834-38-0 C₁₅H₁₀ClF₃N₂O₃ 10 mg
Aurintricarboxylic Acid
Inhibits Apoptosis. Potent inhibitor of DNA topoisomerase II. Stimulates tyrosine phosphorylation of MAP Kinases, Shc proteins, PI-3 Kinase and PLC-γ
Katalog # CAS Nummer Summenformel Menge
sc-3525 4431-00-9 C₂₂H₁₄O₉ 100 mg
Bax Channel Blocker
A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties. Effectively blocks Bid-induced cyctochrome c release from HeLa cell mitochondria by inhibiting Bax channel-forming activity.
Katalog # CAS Nummer Summenformel Menge
sc-221285 n.n. C₁₉H₂₁Br₂N₃O ·2CF₃CO₂H 5 mg
Bongkrekic acid
A mitochondrial permeability transition pore blocker that acts as an inhibitory ligand of the mitochondrial adenine nucleotide translocator. This compound has been shown to inhibit apoptosis by preventing PARP cleavage and DEVDase activity.
Katalog # CAS Nummer Summenformel Menge
sc-205606 11076-19-0 C₂₈H₃₈O₇ ·3NH₃ 100 µg
Bongkrekic Acid, Triammonium Salt
A ligand of the adenine nucleotide translocator.
Katalog # CAS Nummer Summenformel Menge
sc-311298 1177154-51-6 C₂₈H₃₅O₇ ·3NH₄ 500 µg
Calphostin C
Cell permeable, light dependent, potent and highly selective inhibitor of PKC. Inhibits PC-PLD1, PC-PLD2 and induces apoptotic DNA fragmentation.
Katalog # CAS Nummer Summenformel Menge
sc-3545 121263-19-2 C₄₄H₃₈O₁₄ 100 µg/1 mg
CAY10500
Tumor necrosis factor α (TNFα) inhibitor that prevents binding to the TNF Receptor 1 (TNFR1).6 Binds to the biologically active TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. In a cell based assay, compound inhibited TNFα-mediated stimulation of IKB degradation.
Katalog # CAS Nummer Summenformel Menge
sc-223865 n.n. C₃₂H₃₂F₃N₃O₂ 500 µg/1 mg
CAY10578
CK2 is known to negatively regulate apoptosis, and increased activity has been noted in many proliferating tissues and tumors, which lends promise as an anticancer drug target. CAY10578 is a potent inhibitor of CK2 and is ATP competitive, only minimally inhibiting the activities of other protein kinases.
Katalog # CAS Nummer Summenformel Menge
sc-205238 19231-60-8 C₁₀H₃I₄NO₄ 1 mg/10 mg
Chlorogenic Acid
An analog of Caffeic Acid (sc-200499) that displays antioxidant, analgesic, antipyretic and chemopreventive activity.
Katalog # CAS Nummer Summenformel Menge
sc-204683 327-97-9 C₁₆H₁₈O₉ 500 mg/1 g
Colivelin
Katalog # CAS Nummer Summenformel Menge
sc-361153 867021-83-8 C₁₁₉H₂₀₆N₃₂O₃₅ 500 µg
Gambogic amide
A selective agonist for TrkA which mimics the actions of NGF. This compound possesses robust neurotrophic actvity, while it prevents neuronal cell death 1.
Katalog # CAS Nummer Summenformel Menge
sc-221655 n.n. C₃₈H₄₅NO₇ 1 mg/5 mg
Guanosine 3’5’-cyclic Monophosphate, Sodium Salt
An important intracellular second messenger that interacts with the extracellular signals NO and natriuretic peptides.
Katalog # CAS Nummer Summenformel Menge
sc-202172 40732-48-7 C₁₀H₁₁N₅O₇P ·Na 25 mg
(±)-Huperzine A
Katalog # CAS Nummer Summenformel Menge
sc-218582 120786-18-7 C₁₅H₁₈N₂O 1 mg
(-)-Huperzine A
An inhibitor of AChE. Antagonist of NMDA receptors. Protects against glutamate-mediated excitotoxicity.
Katalog # CAS Nummer Summenformel Menge
sc-200183 102518-79-6 C₁₅H₁₈N₂O 1 mg/5 mg
Hypericin
Inhibits PKC, CKII, MAP Kinase, Insulin R, EGFR, PI-3 Kinase and also noted to possess antiviral activity.
Katalog # CAS Nummer Summenformel Menge
sc-3530 548-04-9 C₃₀H₁₆O₈ 1 mg/5 mg
iMAC2
Katalog # CAS Nummer Summenformel Menge
sc-362750 335166-36-4 C₁₉H₂₀Br₂FN₃.2HCl 10 mg/50 mg
Linomide
Immunomodulator with antitumour properties. Inhibits apoptosis of T-cells in vivo and angiogenesis in rats.
Katalog # CAS Nummer Summenformel Menge
sc-204057 84088-42-6 C₁₈H₁₆N₂O₃ 10 mg/50 mg
Maslinic Acid
A pentacyclic triterpene with antioxidant and anti-inflammatory properties. Shown to block the generation of nitric oxide, and inhibits the secretion of IL-6 and TNF-α induced by lipopolysaccharides
Katalog # CAS Nummer Summenformel Menge
sc-221873 4373-41-5 C₃₀H₄₈O₄ 1 mg/5 mg
Mdivi-1
A compound that inhibits the mitochondrial division dynamin-related GTPase.
Katalog # CAS Nummer Summenformel Menge
sc-215291 338967-87-6 C₁₅H₁₀Cl₂N₂O₂S 5 mg/25 mg
Me-7BIO
Control compound for 6BIOand 7BIO.
Katalog # CAS Nummer Summenformel Menge
sc-221878 n.n. C₁₇H₁₂BrN₃O₂ 1 mg
Naringin hydrate
A citrus bioflavonoid found to inhibit cytochrome P450 monooxygenase activity in mouse liver. It prevents toxin-induced cytoskeletal disruption and apoptotic liver cell death.
Katalog # CAS Nummer Summenformel Menge
sc-203443 10236-47-2 (anhydrous) C₂₇H₃₂O₁₄ ·xH₂O 10 g/50 g
Necrostatin-1
An inhibitor of necroptosis, a non-apoptotic cell death pathway. Does not affect Fas/TNFR-triggered apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-200142 4311-88-0 C₁₃H₁₃N₃OS 20 mg/100 mg
Necrostatin-1, Inactive Control
A cell-permeable N-demethylated thiohydantoin analog of Nec-1, devoid of anti-necroptotic properties and serves as a suitable inactive control.
Katalog # CAS Nummer Summenformel Menge
sc-204815 64419-92-7 C₁₂H₁₁N₃OS 5 mg
NSC348884 hydrate
This product is a nucleolar phosphoprotein that displays several biological activities in ribosome biogenesis, cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, centrosome duplication and molecular chaperoning, and is found in higher levels in tumor cells. Overexpression has been shown to lead to inhibition of apoptosis. NSC34884 upregulates p53.
Katalog # CAS Nummer Summenformel Menge
sc-301483 n.n. C₃₈H₄₀N₁₀•xH₂O 5 mg
Orsellinic acid
Benzoic acid. Blocks PAF-mediated neuronal apoptosis. Shows free radical scavenging activity.
Katalog # CAS Nummer Summenformel Menge
sc-202752 480-64-8 C₈H₈O₄ 1 mg
Pidotimod
A synthetic dipeptide with immunological modulatory activity on both the adaptive and innate immune responses.
Katalog # CAS Nummer Summenformel Menge
sc-204846 121808-62-6 C₉H₁₂N₂O₄S 1 g/5 g
Q-VD-OPH
A selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3, caspase-1, caspase-8 and caspase-9.
Katalog # CAS Nummer Summenformel Menge
sc-222230 n.n. C₂₆H₂₅F₂N₃O₆ 5 mg
R5C3
Katalog # CAS Nummer Summenformel Menge
sc-215783 753504-14-2 C₃₃H₂₈N₂O₆ 5 mg
Razoxane
Inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor).
Katalog # CAS Nummer Summenformel Menge
sc-253425 21416-67-1 C₁₁H₁₆N₄O₄ 5 mg
Suptopin-2
Suppressor of topoisomerase II inhibition. Reverses cell cycle arrest; bypass of checkpoint function. Has inherent fluorescence and a distinct advantage in identification of molecule targets; effective concentraion in the µM range.
Katalog # CAS Nummer Summenformel Menge
sc-253617 331852-66-5 C₁₇H₁₆O₇ 10 mg
tetramethyl Nordihydroguaiaretic Acid
A synthetic derivative of NDGA and a non-selective lipoxygenase inhibitor. It inhibits Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter (a gene essential for HSV replication).
Katalog # CAS Nummer Summenformel Menge
sc-224304 24150-24-1 C₂₂H₃₀O₄ 50 mg/100 mg
thio-Miltefosine
A sulfur-containing derivative of miltefosine. Miltefosine is an inhibitor of phosphocholine cytidylyl transferase (CTP) and has antimetastatic properties. At concentrations of 3 and 25 µM, miltefosine inhibits proliferation of HaCaT cells (immortalized human keratinocyte cell line) by 50% and 94%, respectively. The mechanism of action of miltefosine is not well established, but the antiproliferative effect may be mediated by an increase in cellular ceramide which results in apoptosis. Miltefosine is more than 90% effective in eradicating visceral infections of Leishmania species (kala azar), but the mechanism of this antiprotozoal activity is also poorly understood.
Katalog # CAS Nummer Summenformel Menge
sc-222351 n.n. C₂₁H₄₆NO₃PS 1 mg/5 mg
Trimidox
A specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC₅₀ value of 35 µM.
Katalog # CAS Nummer Summenformel Menge
sc-222372 95933-74-7 C₇H₈N₂O₄ 5 mg/10 mg