Apoptosis Inducers

1-β-D-Arabinofuranosylcytosine
An antimetabolic agent which inhibits DNA polymerases α, δ, and ε, and RNA polymerases resulting in suppression of DNA synthesis and repair.
Katalog # CAS Nummer Summenformel Menge
sc-201628 147-94-4 C₉H₁₃N₃O₅ 1 g
1,4-Benzoquinone
Katalog # CAS Nummer Summenformel Menge
sc-202873 106-51-4 C₆H₄O₂ 100 g
1α,25-Dihydroxyvitamin D3 (Calcitriol)
A metabolite of vitamin D₃ and the active form of the hormone. Regulates transport and use of calcium in bone development. Signaling agent in a range of developmental pathways.
Katalog # CAS Nummer Summenformel Menge
sc-200419 32222-06-3 C₂₇H₄₄O₃ 50 µg
2-Amino-N-quinolin-8-yl-benzenesulfonamide
An apoptosis inducer that inhibits cell cycle at G2 phase.
Katalog # CAS Nummer Summenformel Menge
sc-213750 16082-64-7 C₁₅H₁₃N₃O₂S 5 mg
2-Chloro-2′-deoxyadenosine
A deoxyadenosine analog that induces apoptosis in chronic lymphocytic leukemia (CLL) cells.
Katalog # CAS Nummer Summenformel Menge
sc-202399 4291-63-8 C₁₀H₁₂ClN₅O₃ 10 mg
2,3-DCPE
2,3 DCPE displays anticancer agent properties and induces ERK activation. Induces S-phase arrest and upregulates p21.
Katalog # CAS Nummer Summenformel Menge
sc-200139 418788-90-6 C₁₁H₁₅Cl₂NO₂ ·HCl 5 mg/25 mg
3,3'-Diindolylmethane
Anticancer and antineoplastic agent. Induces apoptosis in human cancer cells. Activator of cytochrome P450 and partial agonist of aryl hydrocarbon receptor (AhR). Dimer of indole-3-carbinol (sc-202662).
Katalog # CAS Nummer Summenformel Menge
sc-204624 1968-05-4 C₁₇H₁₄N₂ 100 mg/500 mg
4-Hydroxyphenylretinamide
A synthetic retinoid analog of all trans retinoic acid, which displays antiproliferative effects on cultured human breast cancer cells.
Katalog # CAS Nummer Summenformel Menge
sc-200900 65646-68-6 C₂₆H₃₃NO₂ 5 mg/25 mg
5-[(1Z)-2-(3,5-dimethoxyphenyl)ethenyl]-2-methoxy-phenol
Resveratrol is a natural polyphenolic antioxidant that has anti-cancer properties. This chemical is an analog of resveratrol which is a potent inducer of apoptosis in promyelocytic leukemia HL-60 cells (IC50 = 40 nM versus 50 μM for resveratrol). In addition, it induces apoptosis (IC50 = 30 nM) in HL60R, a cell line derived from HL-60 that expresses a multidrug-resistance phenotype (resistant to daunorubicin, etoposide, and citarabine).
Katalog # CAS Nummer Summenformel Menge
sc-290709 586410-08-4 C₁₇H₁₈O₄ 500 µg/1 mg
5′-Deoxy-5′-methylthioadenosine
A naturally-occurring co-product of polyamine biosynthesis that acts as a substrate of methylthioadenosine phosphorylase.
Katalog # CAS Nummer Summenformel Menge
sc-202427 2457-80-9 C₁₁H₁₅N₅O₃S 50 mg
7BIO
A 3′ substituted kinase inhibitory bis-indole, which functions as a caspase independent nonapoptotic cell death inducer.
Katalog # CAS Nummer Summenformel Menge
sc-221118 n.n. C₁₆H₁₀BrN₃O₂ 5 mg/25 mg
10058-F4
A c-Myc inhibitor that prevents c-Myc/Max dimerization. Also shown to arrest cell growth at G₀/G₁ phase and eventually lead to apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-213577 403811-55-2 C₁₂H₁₁NOS₂ 5 mg/25 mg
13(S)-HPODE
13(S)-HPODE is a hydroperoxide shown to be a potent suppressor of platelets.
Katalog # CAS Nummer Summenformel Menge
sc-200964 33964-75-9 C₁₈H₃₂O₄ 50 µg/1 mg
A23187
Highly selective calcium ionophore. Tool useful for increasing intracellular Ca²⁺ concentrations. Shown to induce cell activation, differentiation or proliferation.
Katalog # CAS Nummer Summenformel Menge
sc-3591 52665-69-7 C₂₉H₃₇N₃O₆ 1 mg/10 mg
AAPH
AAPH is a commonly applied free radical initiator for experimental use.
Katalog # CAS Nummer Summenformel Menge
sc-202034 2997-92-4 C₈H₁₈N₆ ·2HCl 1 g
Adapalene
Retinoic acid analog that is a RARβ and RARγ agonist (AC50 values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro. Displays comedolytic activity.
Katalog # CAS Nummer Summenformel Menge
sc-203803 106685-40-9 C₂₈H₂₈O₃ 10 mg/50 mg
Adenosine
Induces apoptosis in human leukemia HL-60 cells. Has anti-arrhythmic properties.
Katalog # CAS Nummer Summenformel Menge
sc-291838 58-61-7 C₁₀H₁₃N₅O₄ 1 g/5 g
Alendronate, Sodium Salt
A nitrogen-containing bisphosphate that acts as a robust inhibitor of bone resorption and induces apoptosis, and is a selective inhibitor of farnesyl diphosphate synthase.
Katalog # CAS Nummer Summenformel Menge
sc-202049 121268-17-5 C₄H₁₂NNaO₇P₂ ·3H₂O 100 mg
AM 80
Retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Displays anticancer activity against acute promyelocytic leukemia in vivo and exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively).
Katalog # CAS Nummer Summenformel Menge
sc-203816 94497-51-5 C₂₂H₂₅NO₃ 10 mg/50 mg
Antimycin A
An antibiotic that induces apoptosis, inhibits the mitochondrial electron transport chain from cytochrome b to cytochrome C₁, and generates ROS.
Katalog # CAS Nummer Summenformel Menge
sc-202467 1397-94-0 C₂₈H₄₀N₂O₉ 5 mg/10 mg
API-1
Katalog # CAS Nummer Summenformel Menge
sc-361106 36707-00-3 C₁₃H₁₅N₅O₆ 10 mg
Apoptolidin
A selective polyketide, apoptosis inducer produced by Nocardiopsis mainly inducing cell death in E1A-transformed cells and inhibiting the enzymatic activity of mitochondrial F0F1-ATPase.
Katalog # CAS Nummer Summenformel Menge
sc-202062 194874-06-1 C₅₈H₉₆O₂₁ 100 µg
Apoptosis Activator 2
Cell-permeable indoledione compound that activates caspases in a cytochrome c-dependent manner.
Katalog # CAS Nummer Summenformel Menge
sc-202956 79183-19-0 C₁₅H₉Cl₂NO₂ 5 mg
Apoptosis Activator VII, Apoptozole
A cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70 and its inducible homologue Hsp70.
Katalog # CAS Nummer Summenformel Menge
sc-221257 n.n. C₃₃H₂₄F₆N₃O₃ 10 mg
Atractyloside Dipotassium Salt
Katalog # CAS Nummer Summenformel Menge
sc-363293 102130-43-8 C₃₀H₄₄K₂O₁₆S₂ 1 mg
Auraptene
A compound with anti-inflammatory, chemopreventive, apoptotic, cancer cell line suppression, PPAR agonism and MMP-7 translational control properties.
Katalog # CAS Nummer Summenformel Menge
sc-202477 495-02-3 C₁₉H₂₂O₃ 5 mg/25 mg
Baccatin III
Katalog # CAS Nummer Summenformel Menge
sc-204637 27548-93-2 C₃₁H₃₈O₁₁ 5 mg/25 mg
Bcl-2 Inhibitor
This contains a mixture of two tautomers (A and B). A potent, cell-permeable, Bcl-2 inhibitor that competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-x in vitro (IC₅₀ 10 µM and 7 µM, respectively). It also reduces cell viability and growth in HL-60 cell lines with high Bcl-2 expression (IC₅₀= 4 µM). Also induces apoptosis in a dose-dependent manner in cancer cells exhibiting high Bcl-2 expression with little effect on cancer cells with low Bcl-2 expression.
Katalog # CAS Nummer Summenformel Menge
sc-221286 383860-03-5 C₁₆H₁₆N₂O₄ 5 mg
Bcl-2 Inhibitor II, YC137
A cell-permeable naphthoquinone compound that selectively induces apoptosis of Bcl-2-overexpressing cells with little effect on a variety of primary cells.
Katalog # CAS Nummer Summenformel Menge
sc-221287 n.n. C₂₄H₂₁N₃O₆S₂ 5 mg
Bcl-2 Inhibitor III, EM20-25
A cell-permeable pyrimidine-trione compound that sensitizes apoptosis-resistant, Bcl-2-overexpressing leukemic cells to cytotoxic drugs. It has shown to bind to Bcl-2, disrupt its interaction with Bax as well as activate caspase-9. It also induces PTP (permeability transition pore) opening in both isolated mitochondria and intact cells, without any effect on respiration.
Katalog # CAS Nummer Summenformel Menge
sc-221288 141266-44-6 C₁₅H₉CLN₄O₆ 10 mg
Benzalkonium Bromide
This compound functions as an ulcerative agent and preservative in most ophthalmic topical solutions. On epithelial conjunctival cells in vitro, cells die by necrosis at high concetrations and by apoptosis at low concentration.
Katalog # CAS Nummer Summenformel Menge
sc-205600 91080-29-4 C₂₁H₃₈BrN 100 g/500 g
Berberine hemisulfate
Berberine Hemisulfate is a compound that exhibits anti-inflammatory, anti-diabetic, pro-cardiovascular, cholesterol lowering, anti-tumor and anti- depressant activity.
Katalog # CAS Nummer Summenformel Menge
sc-202496 633-66-9 C₂₀H₁₈NO₄•&frac₁₂;SO₄ 1 g
Bestatin Methyl Ester
A cell-permeable derivative of Bestatin which displays slightly stronger inhibition of neutral aminopeptidase than Bestatin, but has much weaker activity against basic aminopeptidase. It also augments Fas- or TNF-α-induced apoptosis in solid tumor cell lines.
Katalog # CAS Nummer Summenformel Menge
sc-221350 65322-89-6 C₁₇H₂₆N₂O₄ 5 mg
Betamethasone
Katalog # CAS Nummer Summenformel Menge
sc-204647 378-44-9 C₂₂H₂₉FO₅ 100 mg/500 mg
BH3I-1
This is a cell permeable BH3 mimetic that binds to Bcl-XL.
Katalog # CAS Nummer Summenformel Menge
sc-221352 300817-68-9 C₁₅H₁₄BrNO₃S₂ 5 mg
BH3I-1"
This is a cell permeable BH3 mimetic that binds to Bcl-XL.
Katalog # CAS Nummer Summenformel Menge
sc-221354 n.n. C₁₅H₁₅NO₃S₂ 5 mg
BH3I-2'
A cell-permeable BH3 mimetic that induces apoptosis by specifically preventing BH3 domain-mediated interaction between pro-apoptotic and anti-apoptotic members of the Bcl-2 family. Reported to block the interaction between Bak BH3 and Bcl-x by targeting the Bcl-x binding pocket.
Katalog # CAS Nummer Summenformel Menge
sc-221355 315195-18-7 C₁₉H₁₁Cl₃INO₄S 1 mg
C2 Ceramide (N-Acetylsphingosine, D-erythro)
A cell-permeable ceramide and potent modulator of cell proliferation and differentiation.
Katalog # CAS Nummer Summenformel Menge
sc-201375 3102-57-6 C₂₀H₃₉NO₃ 5 mg/25 mg
C75
Inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice. Exhibits irreversible slow-binding biphasic inactivation of fatty acid synthase.
Katalog # CAS Nummer Summenformel Menge
sc-202511 191282-48-1 C₁₄H₂₂O₄ 1 mg/5 mg
CD 2665
A selective RARβ/γ antagonist (KD values are 110, 306 and > 1000 nM for RARγ, RARβ and RARα respectively). Shown to block retinoic acid-induced apoptosis ex vivo.
Katalog # CAS Nummer Summenformel Menge
sc-293988 170355-78-9 C₃₁H₃₄O₅•xH₂O 10 mg/50 mg
CD 437
Cell-permeable retinoid-related molecule. Induces tumor growth arrest and apoptosis. The mechanism is not yet understood. Studies suggest CD437/AHPN functions as an ER stress inducer.
Katalog # CAS Nummer Summenformel Menge
sc-202527 125316-60-1 C₂₇H₂₆O₃ 5 mg
Chaetocin
An inhibitor of lysine-specific histone methyltransferase effects, which are essential for gene expression patterns during cell differentiation. Also reported to induce apoptosis in some murine cancer cells.
Katalog # CAS Nummer Summenformel Menge
sc-200893 28097-03-2 C₃₀H₂₈N₆O₆S₄ 200 µg
Chlorambucil
A nitrogen mustard bifunctional alkylating agent. Displays antineoplastic and immunosuppressant effect. Induces apoptosis in chronic lymphocytic leukemia cells.
Katalog # CAS Nummer Summenformel Menge
sc-204682 305-03-3 C₁₄H₁₉Cl₂NO₂ 250 mg/1 g
CHM 1
Katalog # CAS Nummer Summenformel Menge
sc-361147 154554-41-3 C₁₆H₁₀FNO₃ 10 mg/50 mg
CHM-1 hydrate
A potent, selective antitumor agent in human hepatocellular carcinoma. CHM-1 induces apoptosis, and it binds tubulin and inhibits tubulin polymerization.
Katalog # CAS Nummer Summenformel Menge
sc-214686 154554-41-3 (anhydrous) C₁₆H₁₀FNO₃ ·H₂O 5 mg/25 mg
Chrysin
Antioxidant flavonoid. Displays anti-inflammatory and antitumor properties. Inhibits hypoxia-inducible factor-1α (HIF-1α) and induces apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-204686 480-40-0 C₁₅H₁₀O₄ 1 g
CIL-102
A semisynthetic alkaloid derivative, which inhibits cell growth in a wide variety of cancer cell lines in a dose dependent manner.
Katalog # CAS Nummer Summenformel Menge
sc-214722 479077-76-4 C₁₉H₁₄N₂O₂ 10 mg
Citrinin
Katalog # CAS Nummer Summenformel Menge
sc-358726 518-75-2 C₁₃H₁₄O₅ 5 mg/25 mg
cis-3,4',5-Trimethoxy-3'-aminostilbene
A Resveratrol derivative which shows apoptotic activity at nanomolar concentrations. Has an IC₅₀= 0.3. It showed activity toward resistant HL60R cells and their activity was higher than that of several classic chemotherapeutic agents.
Katalog # CAS Nummer Summenformel Menge
sc-217910 586410-12-0 C₁₇H₁₉NO₃ 10 mg
Clodronate, Disodium Salt
A first-generation bisphosphonate and strong inhibitor of osteoclast-mediated bone resorption. Contains cytotoxic effects towards macrophages.
Katalog # CAS Nummer Summenformel Menge
sc-202547 22560-50-5 CH₂Cl₂O₆P₂Na₂ ·xH₂O 10 mg
Colcemid
A cell synchronizing agent that induces coordination of nuclear and cytoplasmic events during cell growth. Also an anti-tubulin agent which blocks cell growth at the mitotic level.
Katalog # CAS Nummer Summenformel Menge
sc-202550 477-30-5 C₂₁H₂₅NO₅ 5 mg
Colchicine
An apoptosis reagent that affects microtubule polymerization and disrupts cytoskeletal formation. Also known to interfere with tissue plasminogen activators.
Katalog # CAS Nummer Summenformel Menge
sc-203005 64-86-8 C₂₂H₂₅NO₆ 1 g/5 g
Concanavalin A
A plant lectin that is a T cell mitogen. It induces apoptosis in human fibroblasts.
Katalog # CAS Nummer Summenformel Menge
sc-203007 11028-71-0 n.n. 50 mg/250 mg
Cyclophosphamide
Katalog # CAS Nummer Summenformel Menge
sc-361165 50-18-0 C₇H₁₅Cl₂N₂O₂P 50 mg
Cyclophosphamide Monohydrate
A widely used antineoplastic agent that also displays immuno-suppressant activity. Induces apoptotic cell death in rat thymus throught Fas/Fas ligand pathway.
Katalog # CAS Nummer Summenformel Menge
sc-202117 6055-19-2 C₇H₁₅Cl₂N₂O₂P ·H₂O 1 g
Cyproterone Acetate
A hepatomitogen and tumor promoter. Induces apoptosis in hepatocytes.
Katalog # CAS Nummer Summenformel Menge
sc-204703 427-51-0 C₂₄H₂₉ClO₄ 100 mg/250 mg
D-erythro-N,N-Dimethylsphingosine
N,N-Dimethylsphingosine inhibits sphingosine kinase, blocking the conversion of sphingosine to sphingosine-1 phosphate.
Katalog # CAS Nummer Summenformel Menge
sc-201373 119567-63-4 C₂₀H₄₁NO₂ 5 mg/25 mg
D-α-Tocopheryl Succinate
An apoptosis agent that triggers caspase-mediated apoptosis at high concentrations and prevents cell proliferation at low concentrations.
Katalog # CAS Nummer Summenformel Menge
sc-200141 4345-03-3 C₃₃H₅₄O₅ 1 g
Deguelin
A natural product that displays profound antiproliferative activity in many tumor cell lines.
Katalog # CAS Nummer Summenformel Menge
sc-200657 522-17-8 C₂₃H₂₂O₆ 5 mg/25 mg
Dexamethasone Sodium Phosphate
A systemic corticosteroid. It induces apoptosis and inhibits sodium phosphate symporter. Used in the treatment of emetic effects of cancer therapy and epicondylitis.
Katalog # CAS Nummer Summenformel Menge
sc-204715 2392-39-4 C₂₂H₂₈FO₈PNa₂ 100 mg/500 mg
Dicoumarol
Reductase inhibitor possessing anticoagulant properties. Aids in apoptosis induction via stimulation of SAPK-JNK and NF-κB pathway blocking. This has no effect on the phosphorylation of P38 or activation of AKT. Also shown to block brefeldin A-dependent mono-ADP-ribosylation in vitro and Golgi disassembly in living cells.
Katalog # CAS Nummer Summenformel Menge
sc-205647 66-76-2 C₁₉H₁₂O₆ 500 mg
Diethylstilbestrol
A synthetic estrogen that induces apoptosis in hormone-insensitive prostate cancer cells.
Katalog # CAS Nummer Summenformel Menge
sc-204720 56-53-1 C₁₈H₂₀O₂ 1 g/5 g
Difluoromethylornithine
An irreversible inhibitor of ornithine decarboxylase which has antiangiogenic activity, inhibits carcinogenesis and induces apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-204723 67037-37-0 C₆H₁₂F₂N₂O₂ 10 mg/25 mg
Disulfiram
A DNA demethylating agent which inhibits prostate cancer cell growth by inhibition of DNA methyltransferase. In addition, studies indicate that Disulfiram inhibits aldehyde dehydrogenase (ALDH) resulting in the accumulation of acetaldehyde upon ethanol ingestion.
Katalog # CAS Nummer Summenformel Menge
sc-205654 97-77-8 C₁₀H₂₀N₂S₄ 50 g/100 g
DMXAA
Apoptosis inducer. Anti-vascular.
Katalog # CAS Nummer Summenformel Menge
sc-207592 117570-53-3 C₁₇H₁₄O₄ 5 mg/25 mg
Docetaxel
A semi-synthetic analog of Taxol. Stabilizes microtubules and inhibits mitosis, leading to apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-201436 114977-28-5 C₄₃H₅₃NO₁₄ 5 mg/25 mg/250 mg
Dolastatin 15
A marine natural product with anti-neoplastic, weak microtubule inhibitor, tubulin inhibitor, hematopoietc progenitor cell inhibitor, as well as immunoglobulin production and leukemia cell proliferation inhibitor
Katalog # CAS Nummer Summenformel Menge
sc-201449 123884-00-4 C₄₅H₆₈N₆O₉ 1 mg
Eeyarestatin I
An endoplasmic reticulum associated degradation inhibitor that suppresses protein translocation and therefore limits the elimination of misfolded proteins from the ER.
Katalog # CAS Nummer Summenformel Menge
sc-358130 412960-54-4 C₂₇H₂₅Cl₂N₇O₇ 10mg
Embelin
Shown to be an antinociceptive and antiinflammatory agent with antioxidative capabilities. Also been reported to induce apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-201555 550-24-3 C₁₇H₂₆O₄ 10 mg/50 mg
Enhancer for Receptors

Katalog # CAS Nummer Summenformel Menge
sc-221586 n.n. n.n. 20 µg
(-)Epicatechin gallate
A polyphenol apoptosis inducer in tumor cells commonly found in green tea. Studies suggest that (-)Epicatechin gallate causes anti-proliferative and anti-inflammatory effects on pancreatic ductal adenocarcinoma cells.
Katalog # CAS Nummer Summenformel Menge
sc-204739 1257-08-5 C₂₂H₁₈O₁₀ 1 mg/5 mg
Erucin
An isothiocyanate from cruciferous vegetable. It is effective inapoptosis induction and mitochondrial potiential dissipation.
Katalog # CAS Nummer Summenformel Menge
sc-204741 4430-36-8 C₆H₁₁NS₂ 25 mg/50 mg
Estren
A steroid ligand that exhibits lower binding affinity for estrogen receptor and has no classical transcriptional activity. Shown to attenuate osteoblast apoptosis, stimulate osteoclast apoptosis, and increase bone mass and strength with no affect to reproductive organs in a non-sex-specific mechanism of action. Possibly useful in studies pertaining to hormone replacement therapy for osteoporosis.
Katalog # CAS Nummer Summenformel Menge
sc-204745 35950-87-9 C₁₈H₂₈O₂ 10 mg
Farnesol
Polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
Katalog # CAS Nummer Summenformel Menge
sc-204748 4602-84-0 C₁₅H₂₆O 50 ml/100 ml
Fludarabine
Prodrug converted to free nucleoside 9-β-D-arabinosyl-2-fluoroadenine (F-ara-A). F-ara-A enters cells and accumulates as 5’-triphosphate. Interferes with DNA synthesis and repair. Induces apoptosis of cancer cells and RNA transcription inhibitor.
Katalog # CAS Nummer Summenformel Menge
sc-204755 21679-14-1 C₁₀H₁₂FN₅O₄ 5 mg/25 mg
Gambogic Acid
Shown to induce apoptosis without affecting the cell cycle. Also reported to decrease Bcl-2 and Bax gene as well as transferrin receptors, which may result in apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-200137 2752-65-0 C₃₈H₄₄O₈ 5 mg/25 mg
Gemcitabine Hydrochloride
Deoxycytidine analog with cytotoxic effects. Inhibits DNA synthesis and induces apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-204763 122111-03-9 C₉H₁₁F₂N₃O₄ ·HCl 25 mg/100 mg
Geranylgeraniol
An intermediate in the mevalonate pathway, that has been shown to prevent bone re-adsorption, inhibition of osteoclast formation, and kinase activation in vitro; reduce toxic effects of statins, without inhibiting cholesterol production.
Katalog # CAS Nummer Summenformel Menge
sc-200858 24034-73-9 C₂₀H₃₄O 20 mg/100 mg
GGTI-298
A cell-permeable, prodrug form of the GGTase I inhibitor GGTI-297. Inhibits the processing of Rap 1A but has no effect on the processing of H-Ras. Also arrests cells in the G0/G1 phase of the cell cycle, induces apoptosis, and enhances iNOS induction by IL-1β.
Katalog # CAS Nummer Summenformel Menge
sc-221673 180977-44-0 C₂₇H₃₃N₃O₃S 250 µg
Gingerol
Shown to activate cardiac and skeletal SR Ca₂⁺-ATPase with apoptosis inducing, antiinflammatory, and antioxidant characteristics.
Katalog # CAS Nummer Summenformel Menge
sc-201519 23513-14-6 C₁₇H₂₆O₄ 5 mg/20 mg
HA14-1
A small, cell-permeable nonpeptidic ligand that binds to the Bcl-2 surface pocket and blocks its biological action. Induces apoptosis in HL-60 leukemic cells overexpressing Bcl-2 and in NIH 3T3 cells via the activation of caspases by a mechanism that is distinct from Fas-mediated apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-205911 65673-63-4 C₁₇H₁₇BrN₂O₅ 5 mg/25 mg
Hexamethylene Biscetamide
Prototype of hybrid polar inducers of apoptosis of various transformed cells.
Katalog # CAS Nummer Summenformel Menge
sc-204772 3073-59-4 C₁₀H₂₀N₂O₂ 25 g/50 g
Hinokitiol
Shown to be a potent iron chelator that inhibits UV B-induced apoptosis in keratinocytes of murine skin. Also demonstrates antimicrobial characteristics.
Katalog # CAS Nummer Summenformel Menge
sc-200812 499-44-5 C₁₀H₁₂O₂ 50 mg/250 mg
HLI 373
HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) which blocks Hdm2-mediated ubiquitylation, proteasomal degradation of p53 and activates p53-dependent transcription.
Katalog # CAS Nummer Summenformel Menge
sc-358833 502137-98-6 C₁₈H₂₃N₅O₂ ·2HCl ·xH₂O 10 mg/50 mg
HMBA
An inhibitor of microtubule polymerization. An apoptosis inducer.
Katalog # CAS Nummer Summenformel Menge
sc-300799 n.n. C₂₂H₁₆O₃ 10 mg
Homoharringtonine
Cephalotaxine alkaloid. Inhibits the formation of diphenylalanine and acetylphenylalanyl-puromycin in liver ribosomes. Has promising activity in hematologic malignancies. Lowers telomerase levels.
Katalog # CAS Nummer Summenformel Menge
sc-202652 26833-87-4 C₂₉H₃₉NO₉ 1 mg/5 mg/10 mg
Honokiol
Biphenyl neolignan and active part of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties. Blocks VEGFR2 autophosphorylation and subsequent rac activation.
Katalog # CAS Nummer Summenformel Menge
sc-202653 35354-74-6 C₁₈H₁₈O₂ 10 mg/100 mg
Idarubicin Hydrochloride
A hydrochloride salt preparation of Idarubicin and an anthracycline analog of daunorubicin. Shown to be an apoptosis inducer that triggers ROS production.
Katalog # CAS Nummer Summenformel Menge
sc-204774 57852-57-0 C₂₆H₂₇NO₉ ·HCl 1 mg/5 mg
Indanocine
A potent cytostatic and cytotoxic indanone that inhhibits tubulin polymerization. Induces apoptotic cell death in stationary-phase multidrug-resistant cancer cells.
Katalog # CAS Nummer Summenformel Menge
sc-221750 n.n. C₂₀H₂₁NO₄ 1 mg
Ionomycin
Highly selective and potent calcium ionophore which serves as a useful tool for increasing intracellular Ca²⁺ concentrations. A non-fluorescent antibiotic and more effective than A23187 (sc-3591).
Katalog # CAS Nummer Summenformel Menge
sc-3592 56092-82-1 C₄₁H₇₀CaO₉ 1 mg/5 mg
Iron Chelator, Dp44mT
A cell-permeable di-2-pyridyl thiosemicarbazone (DpT) based tridentate ligand that displays potent and selective antiproliferative properties in neoplastic cells and minimally affects normal cells. Prevents aggressive growth of M109 lung carcinoma in mice. Shown to mobilize cellular iron effectively, and generate ROS leading to apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-221764 n.n. C₁₄H₁₅N₅S 25 mg
Isoapoptolidin
A ring expanded isomer of apoptolidin. In water, an equilibrium mixture of apoptolidin:isoapoptolidin (~1.5:1) is formed within hours. Used for F0F1-ATPase assays.
Katalog # CAS Nummer Summenformel Menge
sc-202187 476647-30-0 C₅₈H₉₆O₂₁ 100 µg
Jasplakinolide
Binds to F-actin competitively with Phalloidin. Stabilizes F-actin and promotes actin polymerization. Produces antiproliferative and cytotoxic effects.
Katalog # CAS Nummer Summenformel Menge
sc-202191 102396-24-7 C₃₆H₄₅BrN₄O₆ 50 µg/100 µg
Kainic acid
An agonist of the glutamate-recognizing ionotropic kainate receptors. Employed as a tool for inducing excitotoxicity and producing seizures in neurotransmission models.
Katalog # CAS Nummer Summenformel Menge
sc-200454 487-79-6 C₁₀H₁₅NO₄ 5 mg/25 mg
LE 135
Retinoic acid receptor antagonist; displays moderate selectivity for RARβ over RARα; highly selective over RARγ and RXRα. Inhibits human HL-60 leukemia cell differentiation induced by the retinoid Am80.
Katalog # CAS Nummer Summenformel Menge
sc-204053 155877-83-1 C₂₉H₃₀N₂O₂ 10 mg/50 mg
Lipopolysaccharide, Salmonella typhimurium
Katalog # CAS Nummer Summenformel Menge
sc-221857 n.n. n.n. 5 mg
Lovastatin
A hypocholesterolemic statin, inhibits HMGCR and mevalonate biosynthesis. Mevalonate reduction confers inhibition of cholesterol biosynthesis and blocks isoprenylation modification of ras proteins.
Katalog # CAS Nummer Summenformel Menge
sc-200850 75330-75-5 C₂₄H₃₆O₅ 5 mg/25 mg
Methylprednisolone
An apoptosis inducer used in the treatment of lupus nephritis and was also found to inhibit human small cell lung cancer cell growth.
Katalog # CAS Nummer Summenformel Menge
sc-205749 83-43-2 C₂₂H₃₀O₅ 100 mg/500 mg
Mevastatin (Compactin)
An inhibitor of isoprenoid biosynthesis via inhibition of HMG-CoA reductase, and an inducer of neurite outgrowth in neuroblastomas.
Katalog # CAS Nummer Summenformel Menge
sc-200853 73573-88-3 C₂₃H₃₄O₅ 10 mg/50 mg
Mevastatin Sodium
This is the active carboxylate form of mevastatin. It is active in whole cells as well as in cell free assays.
Katalog # CAS Nummer Summenformel Menge
sc-205752 n.n. C₂₃H₃₅NaO₆ 5 mg/25 mg
Miltefosine
A PI3K/Akt inhibitor that also inhibits anti-IgE induced histamine release from skin mast cells. Has been shown to also reduce cytokines IL-1β, IL-4, and IL-6 in certain skin tissue cells.
Katalog # CAS Nummer Summenformel Menge
sc-203135 58066-85-6 C₂₁H₄₆NO₄P 50 mg
MIRA-1
Restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA. Promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC₅₀ = 10μM).
Katalog # CAS Nummer Summenformel Menge
sc-204087 72835-26-8 C₈H₉NO₄ 10 mg/50 mg
Mitomycin C (4% in NaCl)
A reagent used to generate mitotically inactive feeder cells in culture. Mitomycin C (4% in NaCl) is a DNA crosslinking agent which inhibits DNA synthesis and causes apoptosis via a p53-dependent pathway.
Katalog # CAS Nummer Summenformel Menge
sc-286964 50-07-7 (non-salt) C₁₅H₁₈N₄O₅ ·xNaCl 50 mg
Narciclasine
Katalog # CAS Nummer Summenformel Menge
sc-361271 29477-83-6 C₁₄H₁₃NO₇ 1 mg
Necrosis Inhibitor, IM-54
A cell-permeable mono-indolylmaleimide compound that selectively blocks oxidative stress-induced necrotic cell death (~3 µM IM-54 prevented ~50% cell death in HL60 cells exposed to 100 µM H2O2). Does not offer protection against Etoposide induced apoptosis or display antioxidant properties. Does not affect the kinase activities of S6K1 and PKC isozymes even at concentrations as high as 50 µM.
Katalog # CAS Nummer Summenformel Menge
sc-222053 861891-50-1 C₁₉H₂₃N₃O₂ 5 mg
Nigericin•Na
Nigericin, a polyether antibioitc K⁺ and Na⁺ ionophore, stimulates Ca²⁺ release from mitochondria and stimulates ATPase activity.
Katalog # CAS Nummer Summenformel Menge
sc-201518 28380-24-7 C₄₀H₆₇O₁₁··Na 5 mg/1 mg
Nutlin-3
The most commonly used nutlin, nutlin-3 inhibits p53-Mdm2 interaction resulting in antiproliferative activity in treated cells.
Katalog # CAS Nummer Summenformel Menge
sc-45061 548472-68-0 C₃₀H₃₀Cl₂N₄O₄ 1 mg
Noscapine hydrochloride
Opioid alkaloid binds to arresting cells in mitosis, inducing apoptosis and tubulin. Also is an antagonist at bradykinin receptors (pA2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated increases in cAMP levels in CNS tissues. Clinically used antitussive agent.
Katalog # CAS Nummer Summenformel Menge
sc-203650 912-60-7 C₂₂H₂₃NO₇•HCl•xH₂O 100 mg
Oligomycin
A macrolide that acts as a specific inhibitor of the mitochondrial ATP-synthase and blocks oxidative phosphorylation.
Katalog # CAS Nummer Summenformel Menge
sc-203342 1404-19-9 C₄₅H₇₄O₁₁ 10 mg
Oncrasin 1
Proapoptotic substance. Induces abnormal nuclear aggregation of PKCι and suppressing RNA transcription. Displays antiproliferative effects against various human tumor cell lines. Shown to inhibit human xenograft growth by 75% in vivo.
Katalog # CAS Nummer Summenformel Menge
sc-204146 75629-57-1 C₁₆H₁₂CINO 10 mg/50 mg
P-Glycoprotein Inhibitor, C-4
A cell-permeable cinnamoyl compound that reversibly inhibits P-gp (P-glycoprotein) efflux function. Also reverses the MDR (multidrug resistance) phenotype with no effect on P-gp expression. Significantly enhance Paclitaxel- and Vincristine- induced cytotoxicity as well as apoptosis in P-gp expressing KBV20C cells.
Katalog # CAS Nummer Summenformel Menge
sc-222109 n.n. C₂₃H₁₈ClNO₄ 10 mg
p53 Activator III, RITA
A trycyclic thiophene derivative that binds and activates p53 and induces apoptosis. Renal carcinoma research has demonstrated that RITA induces DNA damage, and DNA-DNA, DNA-protein crosslinks.
Katalog # CAS Nummer Summenformel Menge
sc-202753 213261-59-7 C₁₄H₁₂O₃S₂ 1 mg
PAC 1
Procaspase-activating compound; activates procaspase-3 to produce caspase-3. Less efficiently activates procaspase-7.
Katalog # CAS Nummer Summenformel Menge
sc-203174 315183-21-2 C₂₃H₂₈N₄O₂ 10 mg/50 mg
PDK1/Akt/Flt Dual Pathway Inhibitor
A cell-permeable compound that selectively induces apoptosis in AML (Acute Myelogenous Leukemia) with little effect on normal CD34+ AML progenitor cells. Directly inhibit both PDK1 and Akt activities in in vitro kinase assays in a dose-dependent manner and block cellular phosphorylation of Akt at both Ser473 and Thr308. The dual inhibition nature against both PDK1/Akt and Flt3/PIM signaling pathways allows effective elimination of AML cells that are otherwise resistant to inhibitors that target only the PDK1/Akt pathway.
Katalog # CAS Nummer Summenformel Menge
sc-222144 n.n. C₁₀H₄N₆O 5 mg
(-)-Perillyl Alcohol
A monoterpene derived from Lavender, that induces apoptosis in colon tumor cells. Inhibits mammary cancer by inducing hepatocyte phase II enzymes, glutathione-S-transferase.
Katalog # CAS Nummer Summenformel Menge
sc-205798 18457-55-1 C₁₀H₁₆O 10 g/50 g
(+)-Perillyl alcohol
Katalog # CAS Nummer Summenformel Menge
sc-362189 57717-97-2 C₁₀H₁₆O 1 g
PHA 767491 hydrochloride
Potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC₅₀ values are 10 and 34 nM respectively) that prevents initiation of DNA replication. Induces apoptosis in a p53-independent manner in vivo and Inhibits cell proliferation in a variety of human cell lines (IC₅₀ ~ 0.86 - 5.87 μM). Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2) (IC₅₀ = 171 nM).
Katalog # CAS Nummer Summenformel Menge
sc-204187 845714-00-3 C₁₂H₁₁N₃O.ClH 10 mg
Phenylethyl 3-methylcaffeate
Has chemopreventive property against chemically induced colon carcinogenesis. Also amplifies apoptosis in azoxymethane induced colon tumors.
Katalog # CAS Nummer Summenformel Menge
sc-205804 71835-85-3 C₁₈H₁₈O₄ 50 mg/100 mg
PIT 1
Katalog # CAS Nummer Summenformel Menge
sc-361293 53501-41-0 C₁₄H₁₀ClN₃O₄S 10 mg/50 mg
PPAHV
Non-pungent resiniferatoxin-type phorboid vanilloid. Agonist of rat TRPV1 but virtually inactive with human TRPV1. Induces apoptosis through a TRPV-independent mechanism. Tumor promotor.
Katalog # CAS Nummer Summenformel Menge
sc-202296 175796-50-6 C₃₉H₄₄O₁₁ 1 mg/5 mg
Pregnenolone
Endogenous neurosteroid that inhibits GABA-gated chloride currents by enhancing receptor desensitization. Modulates NMDA receptors resulting in delayed apoptotic retinal cell death.Stimulates prostate LNCaP cell proliferation through binding to the mutated androgen receptor.
Katalog # CAS Nummer Summenformel Menge
sc-204860 145-13-1 C₂₁H₃₂O₂ 5 g/25 g
PRIMA-1^MET
Katalog # CAS Nummer Summenformel Menge
sc-361295 5291-32-7 C₁₀H₁₇NO₃ 10 mg
Prodigiosin
A water insoluble, potent proapoptotic compound that belongs to a family of Prodigions isolated from gram-negative bacteria. Also described as a red-pigmented antibiotic produced by Serratia marcescens strains.
Katalog # CAS Nummer Summenformel Menge
sc-202298 82-89-3 C₂₀H₂₅N₃O 500 µg
Quercetin
A hydroxylated flavonoid that causes reversible inhibition of fatty acid synthase. Furthermore, Quercetin has been reported to reduce de novo synthesis of long chain fatty acids.
Katalog # CAS Nummer Summenformel Menge
sc-206089 117-39-5 C₁₅H₁₀O₇ 100 mg/500 mg
Raltitrexed monohydrate
This is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly metabolized to its more potent polyglutamate derivatives.
Katalog # CAS Nummer Summenformel Menge
sc-311520 n.n. C₂₁H₂₂N₄O₆S•H₂O 10 mg
Reveromycin A
The dominant analogue of a complex of spiroketals isolated from Streptomyces. Inhibits the mitogenic activity of EGF. G1 phase cell cycle inhibitor, selectively inhibiting isoleucyl-tRNA synthetase.
Katalog # CAS Nummer Summenformel Menge
sc-202314 134615-37-5 C₃₆H₅₂O₁₁ 100 µg/500 µg
RGD peptide (GRGDNP)
An inhibitor of integrin-ligand interactions. It can induce apoptosis in the absence of signals and integrin-mediated cell clustering.
Katalog # CAS Nummer Summenformel Menge
sc-201176 114681-65-1 C₂₃H₃₈N₁₀O₁₀ 5 mg
(S)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Active enantiomer of AMPA that induces apoptotic cell death in cortical neurons. Does not exhibit any affinity for NMDA receptors.
Katalog # CAS Nummer Summenformel Menge
sc-203250 83643-88-3 C₇H₁₀N₂O₄ 5 mg
Saikosaponin D
Saikosaponin D inhibits cell growth of human cancer cells by inducing apoptosis and blocking cell cycle progression in the G₁ phase. Saikosaponin D was found to stimulate corticotropin-releasing factor (CRF) gene expression and CRF release.
Katalog # CAS Nummer Summenformel Menge
sc-301786 20874-52-6 C₄₂H₆₈O₁₃ 1 mg
Simvastatin, Sodium Salt
Carboxylate form of Simvastatin which is active in whole cells and in cell-free preparations.
Katalog # CAS Nummer Summenformel Menge
sc-222312 12009-77-6 C₂₅H₃₉O₆•Na 5 mg
SJ 172550
SJ 172550 is an MDMX inhibitor which reversibly binds MDMX and inhibits MDMX-p53 interaction in cell cultures.
Katalog # CAS Nummer Summenformel Menge
sc-357403 431979-47-4 C₂₂H₂₁ClN₂O₅ 10mg /50mg
Sodium Butyrate
Shown to cause hyperacetylation of histones via inhibition of histone deacetylase. Also reported to induce differentiation, gene expression, and prevent proliferation.
Katalog # CAS Nummer Summenformel Menge
sc-202341 156-54-7 C₄H₇O₂Na 250 mg/25 g
SU11652
A potent cell-permeable pyrrole-indolinone compound that acts as an ATP-competitive tyrosine kinase receptor and angiogenic inhibitor that exhibits greater selectivity for PDGFRβ (IC₅₀ = 3 nM), VEGFR2 (IC₅₀ = 27 nM), FGFR1 (IC50 = 170 nM), and Kit family members (IC₅₀ ~ 10-500 nM) over EGFR (IC₅₀ >20 µM). Display anti-proliferative and pro-apoptotic properties in tumor cells.
Katalog # CAS Nummer Summenformel Menge
sc-204310 326914-10-7 C₂₂H₂₇ClN₄O₂ 500 µg
Sulindac
Inhibits the NF-κB pathway. Non-steroidal anti-inflammatory drug. Reduces the level and activity of several cyclin-dependent kinases (CDKs) and induces apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-202823 38194-50-2 C₂₀H₁₇FO₃S 1 g
Taxol
An antineoplastic and microtubule affecting agent that causes apoptotic cell death, internucleosomal DNA fragmentation, and inhibition of protein isoprenylation.
Katalog # CAS Nummer Summenformel Menge
sc-201439 33069-62-4 C₄₇H₅₁NO₁₄ 5 mg/25 mg/250 mg
Teniposide
Glycoside-derivative of podophyllotoxin. Has cytostatic effect. Inhibits topoisomerase II while induces apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-204910 29767-20-2 C₃₂H₃₂O₁₃S 25 mg/100 mg
Tetracycline
Used for treatment of chronic inflammatory cells. Tetracycline derivatives induce apoptosis in osteoclasts, Jurkat T lymphocyte cells and in cultured monocytes and macrophages.
Katalog # CAS Nummer Summenformel Menge
sc-205858 60-54-8 C₂₂H₂₄N₂O₈ 10 g/25 g
Thiocolchicine
Inhibitor of microtubules by specific binding to tubulin. Modulator of axonal cytoskeleton. Induces apoptosis. Topoisomerase I inhibitor.
Katalog # CAS Nummer Summenformel Menge
sc-202838 2730-71-4 C₂₂H₂₅NO₅S 100 mg/1 g
TPEN
A cell permeable, high-affinity heavy metal chelator that exhibits low affinity for Mg²⁺ and Ca²⁺. A useful tool for chelation of intracellular Zn²⁺.
Katalog # CAS Nummer Summenformel Menge
sc-200131 16858-02-9 C₂₆H₂₈N₆ 100 mg
Triamcinolone
A glucocorticoid capable of sustaining neuromuscular transmission during early motor nerve degeneration. It is also known to induce apoptosis in T lymphocytes.
Katalog # CAS Nummer Summenformel Menge
sc-204924 124-94-7 C₂₁H₂₇FO₆ 50 mg/250 mg
Tubeimoside I
A triterpenoid saponin isolated from tubers of bolbostemma paniculatum, Franquet, a traditional Chinese medicine "Tu-Bei-Mu". Used as anti-tumor agent, induces cell cycle arrest and apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-204931 102040-03-9 C₆₃H₉₈O₂₉ 10 mg/25 mg
TW-37
Katalog # CAS Nummer Summenformel Menge
sc-361387 877877-35-5 C₃₃H₃₅NO₆S 10 mg/50 mg
UA62784
A specific inhibitor of centromere protein E (CENPE) kinesin-like protein mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.
Katalog # CAS Nummer Summenformel Menge
sc-216036 313367-92-9 C₂₃H₁₅NO₃ 5 mg/25 mg
Valinomycin
Ionophore selective to potassium. Used to induce mitochondrial swelling, CHO apoptotic induction and antagonism of endothelin-induced vasoconstriction.
Katalog # CAS Nummer Summenformel Menge
sc-200991 2001-95-8 C₅₄H₉₀N₆O₁₈ 25 mg
VER-49009
A pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM; produces a cellular antiproliferative GI50 value of 685 nM when tested against a human cancer cell line panel.
Katalog # CAS Nummer Summenformel Menge
sc-357409 940289-57-6 C₁₉H₁₈ClN₃O₄ 500 µg/1 mg
Vinblastine Sulfate
The sulfate of an alkaloid with anti-neoplastic, anti-mitotic, immunosuppressive and apoptotic activity. The compound’s methods of action revolves around inhibition of microtubule assembly and depolymerization of microtubules.
Katalog # CAS Nummer Summenformel Menge
sc-201447 143-67-9 C₄₆H₅₈N₄O₉ ·H₂SO₄ 10 mg/50 mg
Vincristine Sulfate
Shown to bind tubulin via a protein self association reaction. Also shown to contain anti-proliferative characteristics via induction of apoptosis of cells.
Katalog # CAS Nummer Summenformel Menge
sc-201434 2068-78-2 C₄₆H₅₆N₄O₁₀ ·H₂SO₄ 5 mg/25 mg
Xanthorrhizol
An antibacterial and an anti-inflammatory compound that can induce apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-202855 30199-26-9 C₁₅H₂₂O 1 mg
Zearalenone
A phytoestrogenic mycotoxin usually produced by Fusarium species. Also shown to be an anti-proliferative agent that causes mitochondrial release of Cytochrome c and production of ROS.
Katalog # CAS Nummer Summenformel Menge
sc-204943 17924-92-4 C₁₈H₂₂O₅ 10 mg/50 mg