Angiogenesis Inhibitors

• 2-Methoxyestradiol
  An endogenous estrogen metabolite with low affinity for the estrogen receptor but which disrupts microtubule function. Potent inhibitor of endothelial cell proliferation and migration.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201371	362-07-2	C19H26O3	10 mg/50 mg

• 3,5,4'-Trimethoxystilbene
  An antiangiogenic agent and permethylated derivative of Resveratrol (sc-200808) that has been shown to inhibit endothelial cell proliferation, cause microtubule disassembly and tubulin depolymerization.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201450	22255-22-7	C17H18O3	100 mg/500 mg

• 17-DMAG
  A synthetic derivative of Geldanamycin with lower hepatotoxicity. Inhibits HSP90 activity, a cellular chaperone that participates in folding of proteins found in multiple signal transduction pathways.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202005	467214-20-6	C32H48N4O8	1 mg

• Borrelidin
  An anti-angiogenic and anti-microbial compound that disrupts capillary tube formation, and inhibits ThrRS and HUVEC proliferation.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200379	7184-60-3	C28H43NO6	100 µg/1 mg

• Cochlioquinone A
  Major component of a bioactive pigment isolated from Bipolaris leersia. It has been found to be an antagonist of the human chemokine receptor CCR5 in HIV-1. Anti-angiogenic.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202109	32450-25-2	C30H44O8	500 µg

• Cochlioquinone B
  The minor component of a bioactive pigment isolated from Bipolaris leersia, is an NADH ubiquinonereductase inhibitor and a phytotoxic agent inhibiting root growth. It is closely related to Cochlioquinone A.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202110	32450-26-3	C28H40O6	500 µg

• Imiquimod
  A derivative of imidazoquinolinamine that inhibits angiogenesis and is an immune response modifier.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200385	99011-02-6	C14H16N4	100 mg/500 mg

• H-Gly-Pro-Arg-Pro-OH Acetate Salt
  The inhibitor can bind to the polymerization site (D domain) in fibrinogen (K_i = 400 mM) and prevent fibrinogen aggregation and fibrin polymerization.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203071	67869-62-9	C18H31N7O5 ·C2H3O2	5 mg

• Irsogladine maleate
  Irsogladine maleate is a selective PDE4 inhibitor that facilitates gap junction intercellular communication through muscarinic acetylcholine receptor binding.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201190	84504-69-8	C9H7Cl2N5··C4H4O4	50 mg/250 mg

• Mifepristone
  Reported to be an antioxidant and antiangiogenic compound. Also found to demonstrate the ability to suppress activation of NFκB.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203134	84371-65-3	C29H35NO2	50 mg/100 mg

• OGT 2115
  Inhibits heparanase while displaying no major inhibition of human cytocrhome P450 isoenzymes. Displays antiangiogenic propertis in vitro.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204144	853929-59-6	C24H16BrFN2O4	1 mg/10 mg

• Shikonin
  A naphthoquinone derivative that has anti-inflammatory, anti-tumor properties, and can alter chemokine expression and function. Can inhibit proliferation and migration of endothelial cells.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200391	517-89-5	C16H16O5	10 mg/50 mg

• Thiolutin
  A sulfur-based microbial antibiotic that inhibits transcription and mRNA degradation in Streptomyces sp. Also inhibits the adhesion of endothelial cells and induces HSP 27.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200387	87-11-6	C8H8N2O2S2	1 mg/5 mg

• Thalidomide
  Shown to inhibit TNFα biosynthesis and bFGF-induced angiogenesis, induce apoptosis in human monocyte cultures, and to inhibit HIV-1 replication.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201445	50-35-1	C13H10N2O4	100 mg/500 mg

• Tranilast
  An angiogenesis inhibitor that also inhibits the release of histamine and prostaglandins from basophils and mast cells. Reported to inhibit leukotrienes, oxygen radicals, cyclooxygenase-2 expression, cytokines, collagen synthesis, and production of IL-1 and IL-2.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200389	53902-12-8	C18H17NO5	10 mg/50 mg

• Tubulysin A, Myxobacteria sp.
  A cell-permeable atypical amino acid-containing peptide that acts as an anti-microtubule agent with potent antiproliferative and antiangiogenic properties.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-222378	n.n.	C43H65N5O10S	500 µg

• Ursolic Acid
  Reported to be an anti-angiogenic and anti-proliferative compound. Also has been shown to induce cell cycle arrest and apoptosis.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200383	77-52-1	C30H48O3	50 mg/250 mg

• Withaferin A
  Shown to contain potent antiangiogenesis abilities. Also noted to be a proteasome and NFκB activation inhibitor.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200381	5119-48-2	C28H38O6	1 mg/10 mg